COVID-19 Vaccine: Expressing Concerns to Moderna’s Principal Investigators

Expressing Concerns to Moderna’s Principal Investigators

Letter by: Harold R. Gielow, LtCol USMC (Ret)

Recently, Harold R Gielow, LtCol USMC (Ret) sent an email to the principal investigators in Moderna’s mRNA 1273 phase 3, COVID-19 vaccine trial outlining his concerns. He has yet to receive a reply.

The article “Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population” notes that approximately 72% of the US population has preexisting anti-PEG antibodies. The reference further states, “…sensitive detection and precise quantitation of anti-PEG Ab levels in a clinical setting will be essential to ensuring the safe use of PEGylated drugs in all target patient populations going forward.”

As Moderna’s mRNA1273 candidate vaccine uses a pegylated LNP (lipid nanoparticle) vector , what procedures are included in the trial to mitigate this risk?”

Our country is spending billions to fast track and produce a vaccine that over 70% of the population has preexisting antibodies to – to the vaccine! This makes no sense. Additionally, the trial procedures I have read include no steps to mitigate this risk, either to the trial participants or the general public.

BioNTech/Pfizer’s vaccine variants also use a pegylated lipid nanoparticle vector.

many with PEG hypersensitivity go undiagnosed, thus presenting an unreasonable hazard to administering these vaccines to a population, the vast majority of which is proven by science to have anti-PEG antibodies.

I have a severe anaphylactic response to polyethylene glycol. It was diagnosed by Johns Hopkins. I have had multiple ambulance rides and emergency room visits due to inadvertent ingestion/injection with medications containing polyethylene glycol. It is classified by FDA as biologically inert/inactive.  It is anything but that. The incidences of hypersensitivity reactions to PEG are, understandably, increasing, although many with PEG hypersensitivity go undiagnosed, thus presenting an unreasonable hazard to administering these vaccines to a population, the vast majority of which is proven by science to have anti-PEG antibodies. The cited study used blood samples from 1990-1999.  The study showed a steady and dramatic increase in anti-PEG antibodies over time.

PEG is ubiquitous in our environment. It is nearly impossible to avoid, more so as our government classifies it as biologically inactive.

I have communicated my concern to my congressman, my senator, FDA, NIH, the White House, a cousin in biomedical research, multiple scientific writers, and countless others. Perhaps with your background and profile, you can get attention on this issue. I frankly believe not mitigating this risk in a worldwide pandemic situation is gross negligence, Moderna’s scientists having contributed to scientific studies pointing out these issues with polyethylene glycol.”


The above article Expressing Concerns to Moderna’s Principal Investigators originated on Children’s Health Defense and is re-published here by ‘contribution’ with attribution to the articles author Harold R. Gielow, LtCol USMC (Ret) and


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