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Shaken Baby 2a

Preface by: Roger Landry (TLB)

Government corruption and coverups on a massive scale. Parents being blamed for issues out of their control, or actions they took through the blind trust afforded to those whose responsibility it is to keep us and our children safe. Life in prison because of government complicity, or a total lack of responsibility and compassion. This is the world we live in today. This will never change from the top down and it is totally up to us via a ground swell of outrage, to force the drastic changes needed from the bottom up.

What you are about to watch and read is a prime example of what we speak. The following video and accompanying text are the product of one individual who has seen and heard enough to anger her for a lifetime. Christina England is a vital part of The Liberty beacon project. Her experience and in-depth knowledge on the following subject, and much more, make her invaluable to all of us. As a contributor and talk show host in this project we count our blessings continuously for the day she entered our lives.

Please read on and watch this heart wrenching video … it will grab your very soul …

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Article and Video by TLB contributor: Christina England

Parents and caregivers worldwide are being falsely accused of child abuse, when their children develop the so called ‘Shaken Baby Syndrome’ (SBS) triad shortly after a vaccination. Medical and law enforcement professionals dismiss adverse reactions to vaccinations, automatically assuming that injuries have occurred because caregivers are shaking their babies so hard that they cause them to suffer ‘Shaken Baby Syndrome,’ defined by the following triad of serious brain injures:

• Retinal hemorrhages (bleeding into the linings of the eyes);

• Subdural hemorrhages (bleeding beneath the dural membrane which covers the brain);

• Encephalopathy (inflammation and swelling of the brain)

Strange as it seems, medical professionals dismiss adverse reactions to recently administered vaccinations and instead automatically assume that parents and caregivers are guilty of horrendous abuse, including the murder of young children.

This film describes what happens to parents, caregivers and their families when the doctors get it wrong.

I dedicated this film to all the families who have been falsely accused of Shaken Baby Syndrome, especially, Bryant Arroyo who was jailed 20 years ago the murder of his son Jordan. New reports prove that Jordan was suffering from an autoimmune disease and had received multiple vaccinations shortly before he died. Bryant is innocent of any wrong doing.

Links presented in the video:

http://www.thelibertybeacon.com/2014/08/09/death-by-incarceration-life-without-the-possibility-of-parole-lwop/

http://smartvax.com/index.php?option=com_content&view=article&id=103&Itemid=83

http://doc2doc.bmj.com/forums/open-clinical_medicolegal_time-another-look-shaken-baby-syndrome

Video images by: www.freedigitalphoto.net

Please visit Christina at her websites:

http://parentsandcarersagainstinjustice.weebly.com/

www.profitableharm.com

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TLB would like to express our extreme gratitude for Christina’s research, dedication to her fellow human beings and most of all her compassion … as well as Gary Cox for his outstanding technical assistance. Well done !!!

 

CDC

~PRESS RELEASE~

A Study by Focus Autism Foundation Finds: CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Scientists to Support the Fraudulent Application of Government Policies on Vaccine Safety

Whistleblower Says CDC Knew in 2003 of Higher Autism Rate Among African-American Boys Receiving MMR Shot Earlier Than 36 Months

WATCHUNG, NJ–(Marketwired – August 18, 2014) – A top research scientist working for the Centers for Disease Control and Prevention (CDC) played a key role in helping Dr. Brian Hooker of the Focus Autism Foundation uncover data manipulation by the CDC that obscured a higher incidence of autism in African-American boys. The whistleblower came to the attention of Hooker, a PhD in biochemical engineering, after he had made a Freedom of Information Act (FOIA) request for original data on the DeStefano et al MMR (measles, mumps, rubella) and autism study.

Dr. Hooker’s study, published August 8 in the peer-reviewed scientific journal Translational Neurodegeneration, shows that African-American boys receiving their first MMR vaccine before 36 months of age are 3.4 times more likely to develop autism vs. after 36 months.

According to Dr. Hooker, the CDC whistleblower informant — who wishes to remain anonymous — guided him to evidence that a statistically significant relationship between the age the MMR vaccine was first given and autism incidence in African-American boys was hidden by CDC researchers. After data were gathered on 2,583 children living in Atlanta, Georgia who were born between 1986 and 1993, CDC researchers excluded children that did not have a valid State of Georgia birth certificate — reducing the sample size being studied by 41%. Hooker explains that by introducing this arbitrary criteria into the analysis, the cohort size was sharply reduced, eliminating the statistical power of the findings and negating the strong MMR-autism link in African American boys.

Dr. Hooker has worked closely with the CDC whistleblower, and he viewed highly sensitive documents related to the study via Congressional request from U.S. Representative Darrell Issa, Chairman of the House Oversight and Government Reform Committee. The CDC documents from Congress and discussions that Hooker had with the whistleblower reveal widespread manipulation of scientific data and top-down pressure on CDC scientists to support fraudulent application of government policies on vaccine safety. Based on raw data used in the 2004 DeStefano et al study obtained under FOIA, Dr. Hooker found that the link between MMR vaccination and autism in African-American boys was obscured by the introduction of irrelevant and unnecessary birth certificate criteria — ostensibly to reduce the size of the study.

The results of the original study first appeared in the journal Pediatrics which receives financial support from vaccine makers via advertising and direct donations, according to a CBS News report. The DeStefano et al study is widely used by the CDC and other public health organizations to dismiss any link between vaccines and autism — a neurological disorder on the rise.

Dr. Hooker stated “The CDC knew about the relationship between the age of first MMR vaccine and autism incidence in African-American boys as early as 2003, but chose to cover it up.” The whistleblower confirmed this.

When asked if there could be any scientific basis for excluding children born outside of Georgia, Hooker responded, “I know of none, and none has been provided by the authors of the DeStefano study.” He added, “The exclusion is reminiscent of tactics historically used to deprive African-Americans of the vote by requiring valid birth certificates.”

Dr. Hooker concluded further study is needed to determine why this specific effect (3.4-fold increase when MMR is administered prior to 36 months) is seen exclusively in African-American males, and determine whether delaying the first MMR vaccination should be advised for this population. A link between the MMR vaccine and autism has been conceded in cases compensated by the National Vaccine Injury Compensation Program.

The CDC whistleblower informant, who has worked for the government agency for over a decade, remarked to Dr. Hooker in phone calls: “We’ve missed ten years of research because the CDC is so paralyzed right now by anything related to autism. They’re not doing what they should be doing because they’re afraid to look for things that might be associated.” The whistleblower alleges criminal wrongdoing of his supervisors, and he expressed deep regret about his role in helping the CDC hide data.

According to David Lewis, PhD, former senior-level microbiologist with the U.S. EPA’s Office of Research & Development, skewing scientific data to support government policies is a major problem at federal agencies, including EPA, CDC, and USDA. Lewis, who was terminated by EPA for publishing papers in Nature that questioned the science the agency uses to support certain regulations, believes top-down pressure on federal scientists and researchers working on government-funded projects in academia is jeopardizing public health.

“Working for the government is no different than working for corporations. You either toe the line or find yourself looking for another way to make a living,” Lewis says. “No one would be surprised if Merck published unreliable data supporting the safety of its products. Why would anyone be surprised that the CDC is publishing skewed data to conclude that the vaccines it recommends are safe? We need a better system, where scientists are free to be honest.”

The Focus Autism Foundation is dedicated to providing information to the public that exposes the cause or causes of the autism epidemic and the rise of chronic illness — focusing on the role of vaccinations. Learn more at www.Focusautism.org

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Video added by TLB:

SENIOR GOVERNMENT SCIENTIST BREAKS 13 YEARS OF SILENCE ON CDC’S VACCINE-AUTISM FRAUD

AFRICAN AMERICAN BOYS WILLFULLY EXPOSED TO HIGH RISK OF AUTISM FROM MMR VACCINE

 

TLB recommends you visit focus AUTISM for more pertinent articles and information.

See featured article here: http://www.marketwired.com/press-release/-1939179.htm

(NaturalHealth365) Ebola virus disease (EVD), also called ebola hemorrhagic fever, can often be fatal – in its later stages, if poorly treated – due to internal (and external) bleeding, liver and kidney failure. According to the World Health Organization, ebola “is a severe, often fatal illness in humans.” But, the question remains, are we being told everything about this infectious disease?

The Ebola virus CAN be stopped. Conventional medicine admits they have no cure for EVD. Instead of just ‘hoping’ for a recovery – find out how to boost your immunity and eliminate the threat of infectious diseases. If you’re a medical doctor, do not miss our next show.

Simply sign up now for access to our free, weekly show by entering your email address and you’ll receive show times plus FREE gifts!

How does Ebola spread throughout a community?

Humans can get infected through direct contact with the blood or bodily secretions of an infected individual or from infected objects like a needle. Obviously, if you live in an infected community, you must avoid direct contact with those individuals sickened by this disease.

Thanks to movies like Outbreak and Contagion – most people in the United States have scary visions of medical disasters, disease outbreaks, quarantined conditions, martial law and people dying everywhere from a horrific (uncontrollable) virus. Naturally, the ‘solution’ always seems to come in the form of a vaccine – at the last minute of a movie – to save the day.

By the way, unlike what you see in the movies, EVD is not able to be transmitted through the air. I can’t emphasize this enough – the mainstream media has clearly ignored the facts surrounding this disease. And, public health officials have failed miserably at properly informing the public about how to prevent infectious diseases.

On the next NaturalNews Talk Hour, we’ll talk about how to strengthen the immune system and quickly stop viral diseases – within days – safely and effectively.

Simply sign up now for access to our free, weekly show by entering your email address and you’ll receive show times plus FREE gifts!

The most effective vitamin for viral infections and disease prevention

Before we talk about a solution – it’s important to ask: why are people vulnerable to the ebola virus? According to Dr. Levy, “ebola is really an ordinary virus that causes extraordinary pathology in people with a poor nutritional status and a lack of significant antioxidant stores in their bodies.” In other words, well-nourished people are rarely at risk for EVD.

But, if you do get infected – what is the solution? Dr. Levy says, “when addressed in the first few days to a week of a significant exposure or a clinical infection, an aggressive regimen of vitamin C can be expected to routinely resolve the infection and eliminate the virus from the body.”

He goes on to say, ‘the knowledge that vitamin C has this virus-resolving ability can eliminate the need to administer vaccines of questionable benefit but clear side effects because of the knee-jerk reaction that infectious disease doctors have toward all viruses or any other infectious agents that do not readily respond to antibiotic therapy.”

On the next NaturalNews Talk Hour, you’ll learn how to properly administer vitamin C to prevent, even reverse infectious diseases within 24 to 72 hours.

This week’s guest: Thomas E. Levy, MD, JD, board certified internist and cardiologist

Find out how to prevent the threat of the ebola virus safely and naturally – Sun. Aug. 17

Thomas E. Levy, MD, JD is a board-certified internist and cardiologist. He is also bar-certified for the practice of law. He has written extensively on the importance of eliminating toxins while bolstering antioxidant defenses in the body, with particular focus on vitamin C.

His newest book entitled, Death by Calcium: Proof of the toxic effects of dairy and calcium supplements is now available at amazon.com or medfoxpub.com. In this new book, for the first time, Dr. Levy has assembled extensive sections on his treatment protocols for infectious diseases, cancer, heart disease, osteoporosis, plus many other chronic degenerative diseases. This new book contains his detailed “Guide to the Optimal Administration of Vitamin C.” His website is: PeakEnergy.com

Is the fear of ebola justified? To date, according to the Centers for Disease Control, this virus “is centered on three countries in West Africa: Liberia, Guinea, Sierra Leone.” Naturally, people are scared because they have been brainwashed into believing there’s nothing you can do about ebola. Yet, nothing could be further from the truth.

On the next NaturalNews Talk Hour, Jonathan Landsman and Thomas E. Levy, MD, JD will expose the true nature of ebola and the misperceptions of the public. In addition, you’ll learn how to prevent, even reverse all viral attacks and their symptoms like headaches, vomiting, fever, joint and muscle aches plus much more – safely without the need for toxic drugs. This program is a MUST for healthcare professionals.

Jonathan LandsmanAbout the author: Jonathan Landsman is the host of NaturalHealth365.com, the NaturalNews Talk Hour – a free, weekly health show and the NaturalNews Inner Circle – a monthly subscription to the brightest minds in natural health and healing.

Reaching hundreds of thousands of people, worldwide, as a personal health consultant, writer and radio talk show host – Jonathan has been educating the public on the health benefits of an organic (non-GMO) diet along with high-quality supplementation and healthy lifestyle habits including exercise and meditation.

References:

http://www.who.int/mediacentre/factsheets/fs103/en

http://www.cdc.gov/vhf/ebola

http://www.medfoxpub.com/medicalnews/store.html

- See more at: http://www.naturalhealth365.com/natural_cures/ebola-virus-solution-thomas-levy-1108.html#sthash.WC4U9vq7.dpuf

iv-solution

by Thomas E. Levy, MD, JD

(NaturalHealth365) Whether the infectious disease branch of modern medicine is truly unaware or just does not want to admit they are completely wrong on how to cure a viral syndrome remains a debatable point. Certainly, their “find a vaccine for everything” approach to viruses is not the answer.

Even if a vaccine could be introduced into the body without associated toxins and severe side effects that was effective in decreasing the chances of contracting a given viral infection, such an approach does absolutely nothing for the individual who is already critically ill with an overwhelming viral count in the body. And it does nothing for the individuals who remained virus-free yet suffered debilitating side effects.

Can we say the obvious about vaccines?

Of course, no serious attempt has yet been made to detoxify vaccines, and no serious efforts have been made to allay the very real panoply of substantial side effects that so many vaccines can inflict. Even truly effective vaccines, of which there are not many, still do a substantial amount of harm to many individuals who would never have contracted the given infection in the first place.

The interests of the public health are never served by inflicting upon it an array of medical conditions that would never have otherwise existed in the name of preventing a given infection. To add to the concerns that so many individuals have today toward infections that they are lead to believe have no reliable treatments, Hollywood has contributed its own version of hysteria in both TV and movies with the many stories of killer epidemics that are somehow managed just in the nick of time to assure the happy ending.

In these movies, invariably, the epidemics are finally addressed with some ‘magical’ vaccine or antidote. A partial list of such movies includes Contagion, Outbreak, Quarantine, Virus, and even one called Ebola Syndrome.

The Ebola virus can be destroyed naturally – despite what you’ve been told

To date, not a single virus has been tested that is not inactivated (killed) by a large enough dose of vitamin C (ascorbic acid). Many other antioxidants have similar virucidal effects, but vitamin C appears uniquely to be of greatest potency and clinical efficacy, as its simple chemical structure allows for it to be disseminated throughout the body with little restriction.

As such, it is able to effectively address viral populations present in both the intracellular and extracellular spaces. Other antioxidants have been found to have higher ORAC (Oxygen Radical Absorbance Capacity) values – measurements which are used to quantify the antioxidant capacity of supplements (or foods). However, a virus can never be incapacitated by a potent antioxidant if the chemical structure of that antioxidant does not permit direct contact between the virus and the antioxidant.

Vitamin C is both very potent and optimally bioavailable in accessing any viral infection.

Why is vitamin C so effective in killing viruses?

A primary way in which vitamin C destroys viruses, or sets them up for destruction by the immune system, is by activating the ‘Fenton reaction’. In a nutshell, this reaction can proceed inside the virus, inside cells in which viruses are replicating, and on the surfaces of the viruses themselves.

The result of this reaction that is stimulated by the presence of vitamin C, one or more transition metal cations, and the local presence of peroxide is the immediate production of hydroxyl radicals. These radicals are the most reactive oxidizing agents ever identified. As such, they radically upregulate oxidative stress and end up destroying whatever is in their immediate environment.

The effects of vitamin C in “mopping up” after it inflicts its viral damage are further supported by its potent and multifaceted support of the immune system. There is no other substance that singularly does as much to promote increased and strong immune function as vitamin C.

Among many other effects, vitamin C directly stimulates interferon and antibody production, while effectively supercharging the functions of the white blood cells by becoming very concentrated inside those cells.

To be balanced, it is also important to note that the effects of vitamin C on chronic viral infections, such as chronic hepatitis, AIDS, or HIV-positive states are less profound, as the virus works its way into physical locations much less accessible by vitamin C than when the viral infections are acute. Nevertheless, long-term, highly-dosed protocols of vitamin C often completely control and even occasionally cure these diseases.

O.K. – let’s talk about the clinical results

The actual evidence showing what vitamin C has done and can continue to do if properly utilized is there for anyone to see and review. The ‘multi-C protocol’ will reverse and cure any viral syndrome if secondary organ damage has not already advanced too far. Even then, many cases that would seem hopeless can still show dramatic clinical responses.

Review for yourself the incredible clinical results of Frederick Klenner, MD, – who is truly the father of the clinical applications of vitamin C. Also, check out the H1N1 patient in New Zealand who was going to be taken off of life support when vitamin C finally came to the rescue. (it’s the 1st video on the page)

A few more points about Ebola need to be considered…

This is a disease that spreads most effectively among populations that have a substantially poorer nutritional status than is seen in the United States and other well-fed populations around the world. Of course, any exposure to a high enough titer of virus can allow an infection to “take hold,” even in a well-nourished individual.

Furthermore, it has been published that there are a substantial number of individuals, often healthcare workers who treated Ebola patients, who have a symptomless infection when exposed to Ebola virus. This further supports the concept just mentioned that the nutritional status of the exposed individuals is a very important consideration in determining the likelihood of the infection proceeding to severe illness or even death.

My final crucial point about all this ‘hysteria’ …

Don’t worry. If Hollywood and the Centers for Disease Control (CDC) want to induce the populations of the world into a full-blown panic, so be it. You have the tools to prevent a virus like Ebola from ever setting up shop in your body.

And if your prevention should fall short, resolution and cure is a simple process, and it should occur for all but the most immune-challenged, chronically ill, and malnourished individuals among us.

About the author: Thomas E. Levy, MD, JD is a board-certified internist and cardiologist. He is also bar-certified for the practice of law. He has written extensively on the importance of eliminating toxins while bolstering antioxidant defenses in the body, with particular focus on vitamin C.

His new book entitled Death by Calcium: Proof of the toxic effects of dairy and calcium supplements is now available at amazon.com or medfoxpub.com. In this new book, for the first time, Dr. Levy has assembled extensive sections on his treatment protocols for cancer, heart disease, osteoporosis, and other chronic degenerative diseases. As well, this new book contains his detailed “Guide to the Optimal Administration of Vitamin C.” His website is PeakEnergy.com

References:

Baxter A (2000) Symptomless infection with Ebola virus. Lancet 355:2178-2179. PMID: 10881884
Levy T (2002) Curing the Incurable. Vitamin C, Infectious Diseases, and Toxins. Henderson, NV: MedFox Publishing
Klenner F (1971) Observations of the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition 23:61-88
Levy T (2012) Treating influenza with vitamin C: results and mechanisms. Townsend Letter December
Klenner F (1948) Virus pneumonia and its treatment with vitamin C. Southern Medicine & Surgery February, 110:36-38, 46
Cathcart R. (1984) Vitamin C in the treatment of acquired immune deficiency syndrome. (AIDS). Medical Hypotheses 14:423-433. PMID: 6238227
Levy T (2011) Primal Panacea Henderson, NV: MedFox Publishing

Read article here: http://www.naturalhealth365.com/natural_cures/ebola-virus-thomas-levy-1095.html

TLB recommends you read more great/pertinent articles here: http://www.naturalhealth365.com/

 

  • The actor tweeted that side effect of medication Robin was taking is suicide
  • Pair met more than two decades ago on US TV show Saturday Night Live 
  • William’s spokeswoman declined to comment when asked about rumours
  • He took his life last Sunday as his third wife Susan slept in the next room
  • Funeral of the Mrs Doubtfire star could take place as early as this weekend

Preface by: Lucille Femine, Executive Assistant for The Liberty Beacon project

Here surfaces another deeply tragic loss of one of our greatest talents. The cause is now obvious: psychiatric drugs. Who else would be so evil, callous and downright stupid as to prescribe pills for depression that causes suicide?  Please consider the insanity of  this “solution.”

We will miss Robin Williams, as we did others like Judy Garland, Billy Holiday, Earnest Hemingway, Kurt Cobain, Marilyn Monroe and many others.

The artist is the one who shapes and beautifies our culture and gives it future. Psychiatrists, in their irrational fear of the power of beauty and the happiness it brings, tries to destroy it. If they don’t outright kill the artist, they certainly maim him enough to stifle his creativity forever.

However, the artist is simply a favorite target of the psychiatrist and his drugs. Millions more now suffer from this “profession”, including pregnant women, the elderly and children. Be aware of their products which are death and unhappiness, nothing else. For sure, many claim psychiatric drugs have helped them but that is only in the initial stages. After a while, the negative effects kick in – such as depression, violence and suicidal thoughts.

 

The article:

Rob schneider A close friend of Robin Williams has blamed the drugs the comedian was taking to combat Parkinson’s disease for his suicide.

Actor Rob Schneider tweeted: ‘Now that we can talk about it #Robin Williams was on a drug treating the symptoms of Parkinson’s. One of the side effects is suicide.’
Schneider, 50, met Williams more than two decades ago when they appeared on the US TV show, Saturday Night Live. They remained close friends and often performed together in stand-up comedy clubs.

Williams’s spokeswoman declined to comment when asked by The Mail on Sunday about rumours that the tragic comic’s family blames the medication he was on for ‘pushing him over the edge’.

A source said: ‘Robin had recently left rehab. He was on medication for anxiety and depression and had also started taking drugs to combat the early onset of Parkinson’s.

‘Many of these drugs list suicidal thoughts as a possible side effect. A lot of Robin’s friends are convinced that the cocktail of prescription pills he was on somehow contributed to his mental state deteriorating as quickly as it did.

‘Robin had always suffered from depression and addiction but the diagnosis and treatment of his Parkinson’s was new, as was the combination of drugs he was on.’
Williams, 63, was last photographed at an art show near his home in Tiburon, northern California, last Saturday night. He appeared frail and thin.

He took his life last Sunday as his third wife Susan Schneider (who is not related to Rob Schneider) slept in the next room. The pair are thought to have been sleeping in separate rooms because Williams was suffering from insomnia brought on by the drugs he was taking.

Williams’s body was found on Monday morning by his personal assistant. Results of toxicology tests are expected to take six weeks.

More…
• ‘His eyes looked deep set… the impish charm had vanished’: Shock of Robin Williams’ first drama professor as he shares never-before-seen pictures of his ‘genius’ pupil performing in front of royalty in 1971
• Robin Williams’ family members ‘arrive for private memorial service planned by his widow’
• Westboro Baptist Church planning anti-gay protest outside Robin Williams’ funeral – because of late actor’s role in The Birdcage

Experts say Parkinson’s disease can make symptoms of depression worse. America’s National Institute of Mental Health says on its website that people struggling with depression and Parkinson’s ‘suffer higher levels of anxiety and more problems with concentration’ than those suffering from only one of the ailments.

Dr Jeff Bronstein, neurologist specialising in Parkinson’s, said: ‘Obviously getting the diagnosis can make people depressed but we also know there is a much higher incidence of depression even before the disease is recognised. We think it’s one of the early symptoms.’

Robin W withdaughter
Comedian Robin Williams with his daughter Zelda in 2009 before he tragically took his life last Sunday

robin w with wife
He took his life last Sunday as his wife Susan Schneider (not related to Rob Schneider) slept in the next room

The funeral of the star of Good Will Hunting, Good Morning Vietnam and Mrs Doubtfire could take place as early as this weekend.
A source told The Mail on Sunday: ‘The funeral will be private and small for family and very close friends only. There will be larger memorials in Los Angeles and New York at a later date.’

Williams was involved in raising money for Parkinson’s research through his friend Michael J. Fox’s foundation before he was diagnosed with the disease.
Back To The Future star Fox tweeted: ‘Stunned to learn Robin had PD. A true friend. I wish him peace.’

mrs doubtfire
Funeral of the Good Will Hunting, Good Morning Vietnam and Mrs Doubtfire star could take place this weekend

 

Read more: http://www.dailymail.co.uk/tvshowbiz/article-2726920/Actor-Rob-Schneider-says-convinced-Parkinson-s-medication-caused-star-s-suicide.html#ixzz3AeW9Fbb2

TLB recommends you read more great/pertinent articles here: http://www.dailymail.co.uk/ushome/index.html

 

Image by Health Impact News

Image by Health Impact News

Health Impact News Editor Comments:

In this just-published study by Dr. William Shaw in the Journal of Restorative Medicine, strong evidence is presented that acetaminophen (sold as Tylenol or Paracetamol) increases in the rate of autism, asthma, and attention deficit with hyperactivity in genetically and/or metabolically susceptible children. In the United States, acetaminophen is sold as an over-the-counter drug that needs no prescription, in spite of the fact that it results in death for hundreds of Americans each year. Many of the statistics on deaths and injuries due to acetaminophen was revealed in a comprehensive report earlier this year by ProPublica (See: Tylenol is Killing Americans).

The evidence presented in this study is very convincing, as it looked at autism rates in Cuba, where acetaminophen is only available via prescription, and not widely used. Will the FDA finally act to take popular acetaminophen drugs off the market, or are market forces so strong as to prevail, even in the face of such overwhelming evidence?

Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma

By William Shaw, Ph.D.
greatplainslaboratory.com

Abstract

It appears that the marked increase in the rate of autism, asthma, and attention deficit with hyperactivity throughout much of the world may be largely caused by the marked increase in the use of acetaminophen in genetically and/or metabolically susceptible children, and the use of acetaminophen by pregnant women. Toxicity of acetaminophen may cause autism by overloading the defective sulfation pathway catalyzed by phenolsulfotransferase, which is deficient in autism, leading to overproduction of the toxic metabolite N-acetylp- benzoquinone imine (NAPQI). Increased levels of NAPQI reduce the ability to detoxify a host of toxic chemicals in the environment, increasing oxidative stress, which leads to protein, lipid, and nucleic acid damage from free radicals. Epidemiological evidence also supports the association of increased acetaminophen usage with autism, asthma, and attention deficit with hyperactivity. The marked increases in the incidences of autism, asthma, and attention deficit disorder in the United States coincide with the replacement of aspirin by acetaminophen in the 1980s. The characteristic loss of Purkinje cells in the brains of people with autism is consistent with depletion of brain glutathione due to excess acetaminophen usage, which leads to premature brain Purkinje cell death. The anomalous hair mercury concentrations of children with autism are consistent with exposure of growing hair proteins to NAPQI derived from acetaminophen, which competitively inhibits the reaction of mercury with hair sulfhydryl groups. Finally, large-scale faulty production of acetaminophen products, such that the labeled values were exceeded by the true concentrations, in addition to contamination with bacteria and tribromoanisole, may have greatly increased the chances of children receiving overdosages of acetaminophen and potential toxins for perhaps as long as a decade.

Introduction

One of the puzzling aspects of autism is the marked increase in the incidence of autism that began in the United States in the early 1980s and has appeared to increase continuously since then. The highest incidence of autism has been reported to be South Korea, where the incidence is now reported to be one in 38 boys. [1] Increased incidence of autism due to more effective diagnosis was disproved in the study of Irva Hertz-Picciotto who showed that perhaps 12% of the increased autism diagnoses could be attributed to improved diagnosis [2]. A wide range of environmental factors has been associated with increased autism incidence, including pesticides, chemicals, phthalates, polychlorinated biphenyls, solvents, heavy metals or other pollutants. [3] Although toxic chemicals are undoubtedly not beneficial for the health of any person, is there any information that indicates that a toxic avalanche of chemicals inundated the United States in the early 1980s? Indeed a wealth of knowledge about environmental chemicals has led to marked reductions in exposure to chemicals such as lead and dichlorodiphenyltrichloroethane (DDT) in the United States over the past 50 years. For example, acceptable safe limits for levels of lead in the blood have decreased from 60 μg/dL in 1960 to <5 μg/dL in 2010 [4].

Making a connection between disease appearance and causative agent is important. Clinical studies, epidemiological studies and post-market pharmacovigilence are of utmost importance in recognizing signals and drug-induced side effects. One of the most notable cases of serious adverse effects caused by a pharmaceutical agent was the terrible developmental epidemic of the birth of children with seal-like arms and legs (phocomelia) that was linked to the maternal use of the sedative thalidomide 20–35 days after conception [5]. What would have happened if the thalidomide connection had never been made? One of the difficulties with chemical studies of autism associations is that most chemicals are used worldwide, making it difficult to find a “clean” environment where autism might be less prevalent. One of the clues that led to the discovery of thalidomide as the causative agent of deformed limbs was that it was much more commonly used in Europe than in the United States. Countries with the greatest use of thalidomide by pregnant women during pregnancy were those with the highest incidence of deformed babies. If there was a geographic region in the world in which the incidence of autism was much lower than that in the United States, a comparison of medical or dietary differences might provide a significant clue to the major cause of autism.

Such a country is Cuba. The highest estimate of the total incidence of autism in Cuba is 185 cases out of a total population of 11,000,000 (0.00168% of the population) compared with an estimate of as high as 1.5 million in a total United States population of 300 million (0.50%) [6, 7]. The percentage of the population with autism in the United States is thus 298 times higher in the United States than in Cuba. Cuba is much more economically challenged than the United States, with the per capita income of Cuba approximately eight times lower than that in the United States. Despite the economic challenges presented to the communist government of Cuba, basic healthcare is readily available and there are a large number of physicians trained in 14 different medical schools. Unlike the United States, where vaccines are optional in many states, vaccines are compulsory in Cuba and Cuba has one of the most highly vaccinated populations in the world against a wide variety of infectious agents.[8] For example, the vaccination rate for measles was reported to be 99.7%. The association of autism with various vaccines has had a very controversial history with inflamed passions on both sides of the debate and will not be examined here.

However, a topic much less frequently addressed in association with autism is the therapies that are given in conjunction with vaccines. The practice of prescribing acetaminophen as a prophylactic fever preventative is widespread in the United States but is very uncommon in Cuba (personal communications, Dr Olympio Rodriquez Santos MD, MSc, Allergist, Camaguey, Cuba). In the United States, some physicians have started to advise parents to begin to take acetaminophen prophylactically daily 5 days prior to childhood vaccines; some children on such prophylactic treatment had an autistic regression that began prior to vaccination (personal communication, Kerry Scott Lane MD, Anesthesiologist, West Palm Beach, Florida, USA). In Cuba, acetaminophen is not approved as an over-the-counter (OTC) product, however, it has been available as an OTC product since 1959 in the United States. Furthermore, in Cuba, prophylactic use of antipyretic drugs is not the standard medical treatment for vaccine-related fever (personal communications with Dr Olympio Rodriquez Santos). If high fever continues after vaccination in Cuba for more than 2 days, the parents are advised to visit the physician’s office where the drug metamizole is most commonly prescribed. Prescription of acetaminophen in such cases is rare. Metamizole is used in many countries throughout the world but is banned in the United States and some other countries because of a rare association with agranulocytosis.[9]

Could the Use of Certain Antipyretic Drugs, Especially in Conjunction with Vaccines, be a Cause of Autism?

Torres was the first to ask if the suppression of fever by antipyretic drugs commonly used at the time of vaccination might cause the severe immune abnormalities that are prevalent in autism.[10] Schultz et al. were even more specific when indicating in a series of articles that biochemical and immune disorders caused by increased use of the common drug acetaminophen may have caused the autism epidemic (Figure 1).[11–14]

Number of Autistic cases w Events in Acetaminophen lg Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma

Acetaminophen is also termed paracetamol and N-acetyl-p-aminophenol (AAP or APAP). More than 70% of the population in western countries has taken acetaminophen at least once, and a relevant percentage takes the drug chronically as a mild pain reliever and antipyretic.[15] Acetaminophen is used to treat pain and fever and it has become one of the most popular OTC non-narcotic analgesic agents. For example, this compound has been taken at least once by >85% of children under the age of 91 months in the UK.15 In the US, approximately 79% of the general population regularly takes acetaminophen, including more than 35% of pregnant women.[15] Acetaminophen has grown in popularity in large part due to its reputation for safety. For generations, Tylenol® (a popular brand of acetaminophen) advertisements have painted it as “the pain reliever hospitals use most.” Acetaminophen is in >600 OTC and prescription products, from headache and cold remedies to cough syrups and sleep aids.[16]

The study by Schultz et al. was the first to specifically link increased acetaminophen use to increased autism.[11] This study included a graph similar to Figure 1 temporally relating increased autism incidence in California with increased acetaminophen use in the United States and decreased acetaminophen use with decreased rate of autism in California. In addition, similar increases in the rates of asthma correlated with the usage of acetaminophen were also noted by Becker and Schultz.[14] They noted that the rates of autism incidence and asthma stopped increasing in the months following two attempted extortion events in which acetaminophen was deliberately laced with cyanide.[14] The changes in the incidence of these very different diseases at exactly the time acetaminophen use dropped for a significant period of time is remarkable and may indicate the same factor as causing the two diseases. In addition, the autism paper by Schultz et al. included the results of an online survey of parents who had given their child the combined measles, mumps, rubella (MMR) vaccine, which revealed that children with autism had more adverse reactions to the MMR vaccine and were more likely to have been given acetaminophen than ibuprofen for those reactions.[11] Compared with controls, children aged 1–5 years with autism were eight times more likely to have become unwell after the MMR vaccine, and were six times more likely to have taken acetaminophen. Children with autism who regressed in development were four times more likely to have taken acetaminophen after the vaccine. Illnesses concurrent with the MMR vaccine were nine times more likely in autistic children when all cases were considered, and 17 times more likely after limiting cases to children who regressed. There was no increased incidence of autism associated with ibuprofen use.

The incidence of attention deficit with hyperactivity over the last 50 years follows patterns similar to those of autism and asthma, although the data for attention deficit-hyperactivity disorder (ADHD) are not available to the same depth as the data for autism and asthma. Before 1970, the diagnosis of ADHD was relatively rare for schoolchildren and almost nonexistent for adolescents and adults. Between 1980 and 2007, there was an almost 8-fold increase of ADHD prevalence in the United States compared with rates of 40 years ago.[25] Prevalence of ADHD in American schoolchildren was 1% in the 1970s, 3–5% in the 1980s, and 4–5% in the mid-to-late 1990s.[18–24] A study of hospital discharge rates for ADHD between 1989 and 2000 found a 381% increase over the study period.[25]

Use of acetaminophen dramatically increased in the United States in the 1980s due to a concern over an association of aspirin with Reye’s syndrome, although a number of critics reject this hypothesis.[26–28] For example, the current recommendations for the management of children with Kawasaki disease include treatment with high-dose aspirin in the acute phase, and low-dose aspirin during the period of thrombocytosis. For those with residual coronary problems, low-dose aspirin is often given over an even longer term. In Japan alone, up to 200,000 children have received aspirin for Kawasaki disease. Interestingly, only one case of Reye’s syndrome associated with Kawasaki disease has ever been reported, and only in the Japanese literature, giving an incidence of 0.005%.[26] In addition, retrospective reevaluation of patients with a diagnosis of Reye’s syndrome who survived has revealed that many, if not most, had an underlying inborn error of metabolism (IEM).[28] Many of these IEMs had not even been described when the diagnosis of Reye’s syndrome was made. Inborn errors that may mimic Reye’s syndrome include fatty-acid oxidation defects, amino and organic acidopathies, urea-cycle defects, and disorders of carbohydrate metabolism.[28] Future discovery of other IEMs may ultimately explain even more of these cases. Additional etiologies that may mimic Reye’s syndrome include viral infections, neuromuscular diseases, adverse drug reactions, and exposure to toxic chemicals and plants that cause hepatocellular damage and encephalopathy.[28] Diagnostic methods such as GC/MS became more widely available in the 1980s and later so that the patients with IEMs were diagnosed with an IEM instead of Reye’s syndrome. The main cause of Reye’s syndrome appears to be the accumulation of nonesterified fatty acids and lysolecithins that have a high detergent activity and thus denature all proteins.[29]

It is interesting that Cuba, which has a lower autism rate than the United States, allows the use of acetaminophen only by prescription, therefore, the use of acetaminophen in Cuba is only a minuscule fraction of acetaminophen use in the United States and many other countries throughout the world. When acetaminophen use was limited by a prescription requirement in the United States, the rate of autism was a small fraction of current rates of autism.

Unlike thalidomide, which was once promoted for its extreme safety prior to the discovery of its teratogenicity, acetaminophen has a long history of serious side effects associated with its use (Table 1).[47]

 Harmful effects of acetaminophen or its metabolites lg Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma

 Acetaminophen produces neurotoxic effects on rat brain neurons both in vitro and in vivo, its use during pregnancy is associated with teratogenic defects in testicular function and the gastrointestinal tract, and there is increased incidence of asthma in maternally exposed and postnatally exposed children.[13–15, 30, 31, 44-46] Acetominophen is converted to the very toxic metabolite N-acetyl-pbenzoquinone imine (NAPQI; Figure 2), which can cause oxidative damage to proteins, nucleic acids, amino acids, and lipids, in addition to increased mitochondrial and cellular damage and death.[32–35]

Acetaminophen also causes severe immune abnormalities at doses that do not damage the liver, depresses the immune response to vaccination, can cause severe metabolic acidosis when glutathione (GSH) is depleted, is the leading cause of liver failure and death in the United States, is associated with increased rates of certain blood cancers, and results in tens of thousands of visits to the emergency room and hospitalizations in the United States.[14, 36–43] A PubMed search of the scientific literature indicated the presence of 2685 articles regarding acetaminophen toxicity.

An article with the title, “Did acetaminophen cause the autism epidemic?” was more pointed.[48] The rest of this article will deal with the known toxicity of acetaminophen and how other known anatomical, immunologic, biochemical, and infectious aspects of autism can be related to the effects of acetaminophen.

The metabolism of acetaminophen is shown in Figure 2. There are four major pathways for its detoxification. Acetaminophen can be converted to acetaminophen sulfate by phenol sulfotransferase (PST). It can also be converted to a glucuronide or deacetylated to a phenol. In addition, it can be converted to its extremely toxic metabolite NAPQI by the cytochrome P450 (CYP)2E1 enzyme. Several factors that increase the induction of CYP2E1, including smoking, obesity, vinyl chloride, and exposure to trichloroethylene are associated with increased incidence of autism. In addition, acetaminophen exposure itself induces increased CYP2E1, thus increasing the amount of NAPQI formed with each exposure to the drug.[49, 53] Posadas et al. found that acetaminophen exposure to rats resulted in a concentration-related increase in CYP2E1 in rat brains.[15]

Thus, the prophylactic use of acetaminophen for days before vaccination and for multiple vaccinations would likely greatly increase the conversion of acetaminophen to its extremely toxic NAPQI metabolite. Glucuronidation is commonly present at low capacity in the fetus, newborns, and young infants, such that exposure to acetaminophen at these times leads to greater metabolism by other pathways.[54] Acetaminophen can also be deacetylated to form p-aminophenol, which can also be sulfated or converted to an active cannabinoid substance by being conjugated with arachidonic acid to form the conjugate termed AM404.[55] p-Aminophenol may also be detoxified by PST.

Metabolism of acetaminophen paracetamol Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma

Acetaminophen produces analgesia by the activation of the brain endocannabinoid receptor CB1 by AM404.[12, 13] If the sulfation pathway is defective, as has been shown in autism, and/or there is impaired glucuronidation, acetaminophen will be increasingly converted to the alternative metabolic routes, increasing production of its more toxic compounds NAPQI and AM404.[56, 57]

In addition to liver toxicity caused by acetaminophen, individuals without liver toxicity may have severe metabolic acidosis if they are poorly nourished due to illness or dietary insufficiency.[39, 40] In each of these cases, extremely high levels of pyroglutamic acid (also termed 5-oxoproline) are found in both the urine and blood serum. The connection between the elevation of this organic acid and acetaminophen use was first reported by Pitt et al. who suggested that acetaminophen ingestion depletes intracellular GSH stores, which then causes loss of feedback inhibition of γ-glutamylcysteine synthetase activity (Figures 3a and 3b).[40] This increases production of γ-glutamylcysteine, which is partially converted to pyroglutamic acid.

Metabolism of GSH in the absence lg Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma

CYP enzymes are a superfamily of hemoproteins that carry out oxidative metabolism of many endogenous and foreign chemicals.[54] CYP2E1 is the principal CYP responsible for the metabolism of ethanol and is considered to be a major component of the microsomal ethanol-oxidizing system. Among xenobiotics metabolized by CYP2E1 are acetaldehyde, acetaminophen, acrylamide, aniline, benzene, butanol, carbon tetrachloride, diethylether, dimethyl sulfoxide, ethyl carbamate, ethylene chloride, halothane, glycerol, ethylene glycol, N-nitrosodimethylamine, 4-nitrophenol, pyrazole, pyridine, and vinyl chloride.[35] Many of these chemicals are known toxins, established chemical carcinogens, or suspected carcinogens.

Metabolism of GSH after exposure lg Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma

When cyp2e1 knockout mice that lack the ability to produce the CYP2E1 enzyme were challenged with acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this CYP is the principal enzyme responsible for the metabolic conversion of the drug acetaminophen to its active hepatotoxic metabolite NAPQI (Figure 2).[35] During fasting and diabetic ketosis, serum acetone, acetol, and 1,2-propanediol are elevated. CYP2E1 is concomitantly induced due to protein stabilization by acetone.35 Acetone is primarily oxidized to acetol by CYP2E1. As fasting increases ketone production with a concomitant increase in CYP2E1 activity, this in turn increases the production of NAPQI and decreases amino acid substrates for GSH production.[35] Administering acetaminophen is likely to be much more toxic under fasting conditions, such as when a child has an illness that decreases appetite. Children who are sick and fasting and are administered vaccines with prophylactic acetaminophen are much more likely to suffer acetaminophen toxicity.

An examination of the importance of GSH and its biosynthesis is important to an understanding of acetaminophen toxicity. GSH is a tripeptide composed of the amino acids glutamate, cysteine and glycine (Figure 3a). It is present in virtually all aerobic cells at millimolar concentrations where it takes part in numerous fundamental processes. It is a very important antioxidant, participates in detoxification of certain drugs, toxic environmental chemicals, protects against lipid peroxidation and electrophiles, has antiviral effects, is involved in the biosynthesis of DNA, proteins, and leukotrienes, cell proliferation, apoptosis, neurotransmission, and neuromodulation.[58] Decreased levels of GSH are found in several diseases such as liver cirrhosis, pulmonary disease, gastrointestinal or pancreatic inflammation, diabetes, HIV infection, and neurodegenerative diseases.[58] In the normal physiological state (Figure 3a), GSH is produced by the condensation of the amino acids glutamate and cysteine to form the dipeptide γ-glutamylcysteine, which is catalyzed by the enzyme, γ-glutamyl cysteine synthetase.[58] The dipeptide then condenses with the amino acid glycine to form the tripeptide GSH which is catalyzed by the enzyme GSH synthetase. The end product, GSH, exhibits negative feedback inhibition of γ-glutamylsynthetase to prevent the overproduction of GSH. If the amino acid glycine is present at high concentrations, γ-glutamylcysteine is converted in small amounts to pyroglutamic acid that can be recycled to form glutamate.

If GSH is severely depleted by the toxic metabolite of acetaminophen, NAPQI (Figure 3b), and/or there is inadequate glycine to produce GSH due to illness or nutritional deficiency, there is a lack of negative feedback of GSH on γ-glutamylsynthetase.

This severe depletion of GSH results in the synthesis of large amounts of γ-glutamylcysteine, which is increasingly converted to pyroglutamate when glycine is depleted, leading to metabolic acidosis.

As organic acid testing to determine pyroglutamate is usually performed only at specialized pediatric hospitals with specialized biochemical genetics services, the diagnosis of this metabolic disorder in patients may frequently be missed. In addition, NAPQI also deactivates some of the enzymes that recycle GSH, such as GSH peroxidase.[33] The depletion of GSH diminishes the ability of the body to detoxify toxic chemicals. As of 2012, there were 170 articles that indicated an association between toxic chemical exposure and autism.[3] The depletion of GSH will lead to enhanced toxicity of a large number of toxic chemicals. For example, Adams et al. found that variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA, the chelating agent dimercaptosuccinic acid, and the level of red blood cell glutathione.[59] Thus, partial depletion of GSH by moderate increases in NAPQI could lead to enhanced toxicity of heavy metals and perhaps many other toxic chemicals.

Depletion of GSH as a consequence of acetaminophen toxicity to the liver has attracted the most attention in the medical scientific community, as it can frequently be fatal or require a liver transplant or emergency treatment to prevent liver failure (the liver is the organ with the greatest concentration of GSH). However, acetaminophen toxicity has been implicated in a wide range of other disorders in humans and/or experimental animals including cancer, birth defects, asthma, allergies, and brain toxicity (Table 1).

Concentrations of p-aminophenol (which is converted to the cannabinoid substance AM404; Figure 2) from 1 to 100 μg/mL produced significant loss of mouse cortical neuron viability at 24 h compared with the controls.11 The naturally occurring endocannabinoid anandamide also caused similar 24 h loss of cell viability in developing mouse cortical neurons at concentrations ranging from 1 to 100 μg/mL, indicating the mechanism of cell death could be mediated through the cannabinoid receptors. Defective glucuronidation would also increase the conversion of acetaminophen to its more toxic metabolites, NAPQI and AM 404. Such defects in glucuronidation are common in the developing fetus and in newborns.[54]

Posadas et al. found that acetaminophen causes concentration-dependent neuronal death in vitro at concentrations that are reached in human plasma during acetaminophen overdose, and are reached in the cerebrospinal fluid of rats for 3 h following doses that are below those required to induce acute hepatic failure in rats.[15] Acetaminophen also increases both neuronal CYP2E1 enzymatic activity and protein levels, as determined by western blot, leading to neuronal death through mitochondrialmediated mechanisms that involve cytochrome c release and caspase 3 activation. In addition, in vivo experiments show that acetaminophen injection induces neuronal death in the rat cortex. Posadas et al. established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present.[15]

Purkinje Cell Abnormalities, Autism, and GSH Depletion

Ritvo et al. were the first to report abnormalities of Purkinje cells in the cerebella of people with autism.[60] These cells are some of the largest neurons in the human brain, with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines; these neurons utilize γ-aminobutyric acid as their neurotransmitter and send inhibitory projections to the deep cerebellar nuclei, and constitute the sole output of all motor coordination in the cerebellar cortex.[61] The initial study of Ritvo et al. indicated that the number of Purkinje cells in the vermis of the cerebellum was 15 standard deviations below the mean and approximately 8 standard deviations below the mean bilaterally in the cerebral hemispheres of the individuals with autism compared with controls. Vargas et al. found that brain tissues of autistic patients showed extensive neuroglial responses characterized by microglial and astroglial activation.[62] In the brains of autistic patients, the most prominent histological changes were observed in the cerebellum, characterized by a patchy loss of neurons in the Purkinje cell layer and granular cell layer in nine out of ten cerebella; one of these cerebella also showed an almost complete loss of Purkinje cells from the Purkinje cell layer, as well as a marked loss of granular cells. Kern and Jones have summarized the important role of Purkinje cell abnormalities in autism, especially the susceptibility of these cells to oxidative stress during GSH depletion.[63] Such depletion can be due to reduction of GSH due to excessive NAPQI exposure and/or to GSH depletion associated with elevated dopamine secondary to dopamine β-hydroxylase inhibition by phenolic Clostridia metabolites. The metabolite of acetaminophen, 4-amino phenol, also caused depletion of GSH.[64]

Immune Abnormalities Associated with Acetaminophen Use

An important but under-appreciated aspect of acetaminophen toxicity is that direct, drug-induced harm accounts for only part of the overall syndrome of acetaminophen-induced liver injury. The reason for this is that the initial wave of drug-induced hepatocellular destruction is followed by a robust innate immune response, in which invading inflammatory cells release toxic oxidants and cause a second wave of destruction. The collateral damage inflicted by inflammatory cells can be so severe as to double the degree of tissue injury caused by acetaminophen alone.[34]

Prymula and colleagues compared post-vaccine fever and post-vaccine changes in vaccine-specific antibody titers in children who either did or did not receive scheduled acetaminophen with immunizations.[37] Four hundred and fifty nine healthy infants undergoing initial and booster vaccinations for a variety of vaccines were randomized to receive or not to receive prophylactic acetaminophen at the time of and for 24 h after vaccinations. Fever was significantly less common in acetaminophen-treated children after initial and booster vaccination. Children who received acetaminophen had significantly lower antibody titers to each vaccine-related antigen, although it was judged that the titers would probably be protective against the diseases for which they had been immunized. In children with severe sulfation deficiency with a predisposition to autism, vaccination without an adequate immune response might lead to viral infection even with the attenuated strains of the viral vaccines due to a lack of GSH needed for effective immune response.[46]

Acetaminophen sales were high in Englishspeaking countries, and were positively associated with asthma symptoms, eczema and allergic rhinoconjunctivitis in children aged 13–14, and with wheeze, diagnosed asthma, rhinitis and bronchial responsiveness in adults. The prevalence of wheeze increased by 0.52% in 13–14 year olds and by 0.26% in adults (p < 0.0005) for each gram increase in per capita acetaminophen sales. Between 1980 and 2003, the prevalence of pediatric asthma in the United States increased from 3.6% to 5.8%, and similar increases were observed throughout the world.[45] It has been speculated that frequent use of acetaminophen might influence asthma and rhinitis by depleting levels of reduced GSH in the nose and airways, thus shifting the oxidant/antioxidant balance in favor of oxidative stress and increasing inflammation.[44]

Acetaminophen decreases GSH levels, principally in the liver and kidneys, but also in the lungs.[46] These decreases are dose dependent; overdose levels of acetaminophen are cytotoxic to pneumocytes and cause acute lung injury, whereas nontoxic, therapeutic doses produce smaller, but significant reductions in GSH levels in type II pneumocytes and alveolar macrophages.[46] Among healthy young volunteers, significantly lower serum antioxidant capacity has been seen within 2 weeks of ingestion of 1 g of acetaminophen.[46] By depleting GSH levels, acetaminophen weakens the ability of the host to mitigate oxidative stress produced by reactive oxygen species (ROS) such as superoxide anions (O2 −), hydroxyl (•OH), and peroxyl (ROO−) radicals.[46] Finally, when GSH levels are low, defective processing of disulfide bonds that are key in antigen presentation has been hypothesized.[46] It is conceivable that decreased levels of GSH guide the expression of T-helper cell pathways by altering antigen presentation and recognition, thereby favoring the T2 allergic-dominant pathway. In a study of children with autism spectrum disorders (ASDs) in Sweden, airway symptoms of wheezing and physician-diagnosed asthma in the baseline investigation in infants and toddlers were associated with ASD 5 years later.[52]

Skewed T1 or T2 responses were also indicated in ASD children.[65, 66] Analysis by Jyonouchi et al. of adaptive immune responses revealed markedly variable T1rT2 cytokine levels in ASD children compared with control siblings.[67] It has been reported that immune responses in autistic children are relatively skewed to T2 on the basis of intracellular staining of T1rT2 cytokines.[65] Higher levels of IgG, IgA, and IgE allergies to various foods, but especially milk and wheat, have been reported in children with autism, together with abnormal cellular immune responses to milk, wheat, and soy.[67] It has been shown that depleting GSH in brain microglia and astroglia induces a neuroinflammatory response that results in both significant cytokine release and the release of material that is toxic to neurons.

In addition, the ability of GSH to downregulate nuclear factor-kB, and the inverse association between alveolar GSH levels and bronchial responsiveness, suggests that GSH may modify asthma inflammation. Secondly, studies in animals have found that acetaminophen can deplete the lung of GSH. These effects in macrophages raise the possibility that acetaminophen might also influence atopic diseases more generally through another mechanism, namely the promotion of atopy, since depletion of GSH in antigen-presenting cells promotes T-helper cell 2-type cytokine responses. This might explain why, in children, acetaminophen sales were associated with atopic eczema as well as with asthma and rhinitis. As of 2012, 416 studies had demonstrated an association between autism and immune abnormalities and/or inflammation.[3]

The beginning of the rapid increase in autism in around 1980 coincides with the rapid increase in asthma, both of which coincide with the rapid increase in the use of acetaminophen following the Reye’s syndrome scare over a possible association with aspirin.

It would seem likely that perhaps some children on the autistic spectrum might have both brain and lung abnormalities caused by acetaminophen. Is there any evidence for such combined abnormalities? Indeed, at the annual meeting of the American College of Chest Physicians in Honolulu, Hawaii in 2011, Barbara Stewart, a pediatric pulmonologist, found that a significant lung abnormality was present in 100% of children (n = 47) on the autistic spectrum who were examined, but in none of <300 children without autism.68 Most of the children with autism had been referred to her clinic due to persistent cough unresponsive to treatment. She noticed during bronchoscopy examinations, in which a lighted tube is inserted into the lungs, that, although the airways of the children initially appeared normal, the lower airway had doubled branches, or “doublets”. Dr. Stewart said “when airways divide beyond the first generation, they typically branch like a tree, with one branch on one side and one on the other. A doublet occurs when there are twin branches that come off together instead of one, which are exactly symmetrical, in each of the lower locations that can be seen.” In a study of ASD children in Sweden, airway symptoms of wheezing and physician-diagnosed asthma in the baseline investigation in infants and toddlers were associated with ASD 5 years later.[52] It would seem very useful to examine the use of acetaminophen both prenatally and postnatally in the children with the abnormal lung anatomy.

DNA Damage

As of 2012, 145 studies had shown an association between mitochondria function and autism.[3] The data of Cover et al. showed that nitration of mitochondrial proteins and depletion of mitochondrial DNA after acetaminophen overdose in mice was due to peroxynitrite formation.[32] In contrast, nDNA damage was not directly caused by peroxynitrite. Nuclear DNA damage after acetaminophen overdose is likely to be caused by DNase(s) unrelated to the caspase-activated DNase, which is typically responsible for DNA fragmentation during apoptosis. The data from Cover et al. suggest that the activation of these DNase(s) is dependent on the mitochondrial oxidant stress and peroxynitrite formation.[32]

Recent data have demonstrated that nitrated tyrosine residues, as well as acetaminophen adducts, occur in the necrotic cells following toxic doses of acetaminophen. Nitrotyrosine was postulated to be mediated by peroxynitrite, a reactive nitrogen species formed by the very rapid reaction of superoxide and nitric oxide (NO). Peroxynitrite is normally detoxified by GSH, which is depleted in acetaminophen toxicity. NO synthesis (serum nitrate plus nitrite) was dramatically increased following acetaminophen.

NAPQI

The metabolism of acetaminophen (Figure 2) by CYP2E1 forms NAPQI, a reactive metabolite that binds to cysteine residues in cellular proteins and forms acetaminophen protein adducts, referred to as acetaminophen-cysteine complexes (APAP-CYS).

Heard et al. demonstrated that low concentrations of APAP-CYS are detectable in serum following therapeutic dosing with acetaminophen in the vast majority of individuals.[49] The APAP-CYS concentrations following acetaminophen overdose varied widely. Serum APAP-CYS concentrations in patients with hepatic injury following acetaminophen overdose were generally much higher than those observed during therapeutic dosing. However, three overdose patients had APAP-CYS concentrations that were of the same order of magnitude as those observed with therapeutic dosing. Adduct concentrations varied according to the degree of exposure. Currently, an absolute adduct level exceeding 1.1 µmol/L appears consistent with acetaminophen toxicity. While therapeutic dosing generally produces concentrations below 0.5 µmol/L, values in people taking recommended dosages have been reported to be very close to the lower limit of APAP-CYS concentration associated with acetaminophen toxic overdoses (1.0 µmol/L).

NAPQI and Anomalous Hair Metal Values in Autism

Concentrations of the NAPQI metabolite increased to values as high as 1.0 µmol/L or 1000 nmol/L serum following therapeutic doses of acetaminophen. Hair proteins contain a considerable amount of cysteine, and hair proteins in hair follicles and would be expected to react with NAPQI to form NAPQI adducts with cysteine sulfhydryl groups in hair. Such cysteine groups also react strongly with heavy metals such as mercury. In comparison, the mean blood mercury concentration of children with autism was 19.53 nmol/L. Thus the concentration of NAPQI might be as much as 51 times the concentration of total mercury. Since NAPQI amounts are so much higher than mercury values, it would be expected that NAPQI might significantly reduce the capacity of hair proteins to bind mercury if the binding capacity of the hair sulfhydryl groups was exceeded by the previous binding of NAPQI. Such inhibition by NAPQI may help to explain anomalous data in the measurement of mercury in hair samples of children with autism. In two baby hair studies in which samples were obtained at first haircuts, mercury values in hair were much lower in children with autism compared with those of normal controls.[69, 70] In addition, children with the most severe symptoms of autism had the lowest amount of hair mercury. Studies in Kuwait and Saudi Arabia found opposite results in children with autism; children with autism had much higher amounts of hair mercury as well as other heavy metals, but in both of these studies the children were much older (mean ages 8.8 years in Saudi Arabia and 4.2 years in Kuwait) than those in the baby hair studies (12–24 months of age).[71, 72] All of this data could be explained by patterns of acetaminophen drug use in children. Acetaminophen is commonly used prophylactically to prevent fever in infants and toddlers who receive the bulk of their vaccines in the first 2 years of life. In contrast, few vaccines and attendant prophylactic acetaminophen are administered to older children with autism in the age range in which hair mercury values were elevated compared with controls. In these older children, hair metals such as mercury would be considerably higher due to a lack of competition from NAPQI for reactive sulfhydryl groups in hair proteins in the hair follicles.

Special Concerns About the Long-Term Defective Quality Control of Acetaminophen Products

All of the information to this point has been directed to the toxicity of pure acetaminophen. Toxicity is usually due to exceeding the recommended daily dosage, often occurring due to accidental combination use of multiple products containing acetaminophen or through changes in dosage amounts by manufacturers. Adding to this are reports that acetaminophen products have been contaminated at various times, potentially increasing health risks. These problems have been documented in Food and Drug Administration inspection reports and subsequent recalls.

From the time it was introduced in 1955, acetaminophen has become one of the most successful OTC drugs, and has earned the primary manufacturer, Johnson & Johnson, an estimated US$1.3 billion every year.[73] Within the last 10 years, the FDA has chronicled manufacturing problems including mislabeling of children’s tablets, where packages of the product listed an incorrect amount of the ingredients per tablet, inadequate cleaning of equipment used for manufacturing, insufficient follow-up in investigating consumer complaints, product mix-ups, and contamination with metal fragments and bacteria.[74, 75] The latter resulted in a recall of 135 million bottles of children’s medications containing acetaminophen.

Additional recalls occurred in 2009 and 2010 due to trace amounts of the chemical 2,4,6-tribromoanisole found in infant, children, and adult OTC products. This recall was prompted by 775 consumer reports of nausea, vomiting, stomach pains and diarrhea received by FDA due to the contamination.[76] It was found that the chemical 2,4,6-tribromoanisole (a metabolite of a chemical fungicide tribromophenol) was being used in a manufacturing facility to treat the wood used in pallets used for transporting packaged materials.[77] Tribromoanisole is produced when naturally-occurring airborne fungi and/or bacteria (usually Aspergillus sp., Penicillium sp., Actinomycetes, Botrytis cinerea, Rhizobium sp., or Streptomyces) are presented with brominated phenolic compounds, which they then convert into bromoanisole derivatives.

Other FDA-publicized inspection reports of acetaminophen-manufacturing facilities have listed inadequate quality controls, lack of safeguards to isolate “rejected” raw materials and other drugs, and several human errors resulting in product mix-ups.[78] Several recalls have occurred due to failed FDA manufacturing inspections and contaminated products affecting >300 million bottles of adult and children’s medicines.[79, 82] Manufacturing controls are an integral aspect of pharmaceutical production to ensure public safety, and disregard or deficiency can lead to serious outcomes. In response to the high number of inadequacies found through inspections and numerous recalls, US health authorities have taken over supervision of three acetaminophen manufacturing plants to mitigate risks.[83]

A Call to Action

A large-scale, long-term study of both prenatal and postnatal effects of acetaminophen exposure on the incidence of autism, attention deficit with hyperactivity, and asthma should be conducted. However, such a study would probably take at least 5 years. If acetaminophen is indeed the cause of all of these illnesses, should acetaminophen use continue for such a long period of time while millions of additional children are further affected? Respected physicians consider that the connection of acetaminophen with asthma has been proven beyond a reasonable doubt. Dr McBride, Professor of Pediatrics at Department of Pediatrics, Northeast Ohio Medical University, Rootstown, Ohio summarizes the evidence for the acetaminophen asthma findings[45]: “There remains a possibility that confounding variables might explain some or all of the association between acetaminophen and asthma. For this reason we need further studies. At present, however, I need further studies not to prove that acetaminophen is dangerous but, rather, to prove that it is safe. Until such evidence is forthcoming, I will recommend avoidance of acetaminophen by all children with asthma or those at risk for asthma and will work to make patients, parents, and primary care providers aware of the possibility that acetaminophen is detrimental to children with asthma.”

Since all children may be at risk from asthma, Dr. McBride is in effect saying that acetaminophen is contraindicated for the treatment of any children. Although the case for acetaminophen being a cause of autism and attention deficit with hyperactivity may not be as strong as the case for asthma, the severe asthma risk combined with the risks of autism and attention deficit with hyperactivity are so severe that we as a society should maintain a degree of caution with acetaminophen given the proven overall toxicity due to accidental overdose of the drug, and the availability of ibuprofen or abstaining from treatment as alternatives. A large-scale trial of acetaminophen restriction in pregnancy and the first 3 years of life is warranted to test the hypothesis that acetaminophen is a causative agent in autism, asthma, and attention deficit with hyperactivity. Due to the increased risks associated with accidental overuse of acetaminophen, increased public awareness of such risks is paramount.

Given associations of acetaminophen with increased rates of cancer, increased testicular damage, increased rates of asthma, and allergy, plausible causation of autism, and in vitro evidence of brain damage associated with metabolites of acetaminophen, new assessments of the relative risk of aspirin causing Reye’s syndrome versus the risks of acetaminophen in children should be undertaken. If a clear link between acetaminophen use pre- or post-natally and autism is established, medical practice guidelines may need to be adjusted and alternative analgesics or antipyretics, such as ibuprofen, recommended. However, such a relationship may be difficult to establish, as studies may have to account for variations in dosage amounts, formats, combination product use, and for the possibility of product recalls given the recent reported manufacturing issues surrounding acetaminophen.

Note Added in Proof

After this article was submitted for publication on January 2, 2013 the following article was published prior to publication which strongly supports the hypothesis in the current article.

In 2013, Bauer and Kriebel reported that prenatal use of acetaminophen was strongly correlated with autism/Autism Spectrum Disorder prevalence (r = 0.80) using all available country-level data (n = 8) for the period 1984 to 2005. In addition, the authors found that after acetaminophen became commonly used to treat circumcision pain after 1995, there was a strong correlation between countrylevel (n = 9) autism/ASD prevalence in males and a country’s circumcision rate (r = 0.98). A very similar pattern was seen among US states and when comparing the three main racial/ethnic groups in the US.[84]

Reprinted with Permission. Copyright Great Plains Laboratory, Inc. 2013 Original Source.

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See Also: Tylenol is Killing Americans

TLB recommends you visit Health Impact News for more great/pertinent articles and information.

See featured article and read comments here: http://healthimpactnews.com/2013/study-evidence-that-acetaminophen-especially-in-conjunction-with-vaccines-is-a-major-cause-of-autism-and-asthma/

Doctor-Stethoscope-Nurse-Annoyed-Hands-Hips

 

(NaturalNews) As the rubber meets the road for the Affordable Care Act (ACA), many doctors are realizing that the healthcare overhaul simply won’t work for them if they want to actually stay in business. Many private practices, according to reports, are coming to the harsh realization that Obamacare’s reimbursement rates for medical care are dismal, which is why many doctors are choosing to opt out of the program entirely.

It is something that we predicted from the beginning — a very limited network of covered providers that are willing and able to accept lower-than-standard reimbursements. Obamacare’s most avid supporters were vehement in their denial that such a scenario would ever occur, but it is now clear that government-mandated coverage is unsustainable, and that quality of care will decline if doctors are forced to provide coverage at lower rates.

“I cannot accept a plan [in which] potentially commercial-type reimbursement rates were now going to be reimbursed at Medicare rates,” stated Dr. Doug Gerard, a Connecticut-based internist, to NPR. “You have to maintain a certain mix in private practice between the low reimbursers and the high reimbursers to be able to keep the lights on.”

While a normal private insurer would reimburse him about $100 for a standard patient visit, Dr. Gerard says Obamacare’s private insurance plans will only reimburse him about $80, which is roughly equivalent to the Medicare reimbursement rate. Among the three plans available on Connecticut’s Obamacare marketplace, only one of them meets the minimal reimbursement requirements that Dr. Gerard says are necessary for him to provide adequate care.

“I don’t think most physicians know what they’re being reimbursed,” he told NPR. “Only when they start seeing some of those rates come through will they realize how low the rates are they agreed to.”

Obamacare doesn’t even cover cancer treatment in many states

All of this may come as a shock to some who naively assumed that Obamacare would provide equal or greater coverage than true private insurance, but for less money. To quote the words of Connecticut State Medical Society President-elect Bob Russo, who recently spoke to The Daily Caller, “You get what you pay for.”

Nothing in life is free, of course — especially healthcare coverage. Despite the “Obama gon’ pay my mortgage!” sentiment expressed by some who obviously fail in their understanding of simple economics, somebody has to pay for all these added insurance holders who are unable to pay for themselves. In this case, that entity is the federal government via tax dollars, but at a predictably lower rate.

In some cases, even what types of conditions are covered under Obamacare is uncertain. According to The Daily Caller, top-tier hospitals that typically have multiple streams of reimbursement income, including those that treat severe conditions like cancer, are having to reject Obamacare plans, because they simply don’t cover enough of the treatment costs.

“I think it could lead potentially to this kind of distinction that there [are] these different tiers of quality of care,” added Kevin Counihan, the man in charge of Connecticut’s Obamacare marketplace, to NPR about the dilemma.

“The [perception that there are] different tiers of quality of care means somehow that the people think that just because my income is below 400 percent of the federal poverty level, I’m going to get inadequate care or lesser care than someone making above 400 percent.”

Sources for this article include:

http://www.npr.org

http://dailycaller.com

http://www.onenewsnow.com

TLB recommends you read more great/pertinent articles here: http://www.naturalnews.com/index.html

Child vaccination

By TLB Contributor: Christina England

On 7August 2014, Fox6News reported that yet another innocent child had died after receiving the HPV vaccination, Gardasil. This takes the current HPV vaccine reported death toll to 170, according to the sanevax.org website. [1]

Twelve year-old Meredith Prohaska died within hours of receiving the Gardasil vaccination. Rebecca Prohaska, Meredith’s mother, told reporters that her daughter had received the vaccine at around 10:30 am on July 30 and had died later that day.

She stated:

“The only thing different about that day was that shot. I wish I would’ve known more about it before I agreed to it.”

Dr. Geoffrey Swain, a professor and medical doctor at the Milwaukee Health Department, disagreed; he told Fox6News that by and large, the HPV vaccine’s benefits far outweigh the risks. He told reporters:

“Vaccines in general and the HPV vaccine in particular, are very, very safe. It’s a very safe vaccine and very effective.”

Dr. Swain concluded his statement with:

“Serious side effects are nearly one in a million.”

Fox6News reported:

“Rebecca Prohaska remembers a rare potential side effect of the HPV vaccine — an allergic reaction, but Meredith’s autopsy report rules her cause of death as inconclusive.” [2]

However………!

Conflicting Opinions and Information

Despite Dr. Swain’s seemingly reassuring words, one of the leading organizations reporting on the dangers of the HPV vaccines, sanevax.org, paints an entirely different picture. On their homepage, they display a chart documenting over 35,000 adverse reactions reported to the VAERS website (Vaccine Adverse Events Reporting System):

Description     Total  
Disabled     1,156    
Deaths     169    
Did Not Recover     7,111    
Abnormal Pap Smear     572    
Cervical Dysplasia     243    
Cervical Cancer     78    
Life Threatening     640    
Emergency Room     11,705    
Hospitalized     3,679    
Extended Hospital Stay     251    
Serious     4,920    
Adverse Events     35,270  

 

Shockingly, these figures are estimated to represent only 10% of the true figure of vaccine injuries being reported in the US.

To explain this massive under-rerporting of vaccine injuries, Think Twice Global Vaccine Institute stated that:

“In 1986, Congress officially acknowledged the reality of vaccine-caused injuries and death by creating and passing The National Childhood Vaccine Injury Act (Public Law 99-660). The safety reform portion of this law requires doctors to provide parents with information about the benefits and risks of childhood vaccines prior to vaccination, and to report vaccine reactions to federal health officials. Doctors are required by law to report suspected cases of vaccine damage. To simplify and centralize this legal requisite, federal health officials established the Vaccine Adverse Event Reporting System (VAERS) — operated by the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA).

Ideally, doctors would abide by this federal law and report adverse events following the administration of a vaccine. However, the FDA recently acknowledged that 90 percent of doctors do not report vaccine reactions. They are choosing to subvert this law by claiming the adverse event was, in their opinion, not related to the shot.” [3] (emphasis added)

Using the figures reported by sanevax.org, the actual number of adverse reactions following a HPV vaccination could be as high as 352,700.

What the Experts Say About the HPV Vaccines

In 2013, Dr. Lucija Tomljenovic et al., wrote an article/letter in response to an editorial written by Silvia de Sanjosé. The professionals made their opinions on the HPV vaccination abundantly clear.

Their abstract stated:

“The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in order to decrease the burden of cervical cancer. Careful analysis of HPV vaccine pre- and post-licensure data shows however that both of these premises are at odds with factual evidence and are largely derived from significant misinterpretation of available data.”

They continued:

“It is also noteworthy that Mercks HPV vaccine Gardasil received priority Fast Track approval by the U.S. Food and Drug Administration (FDA) after a 6-month review process, despite the fact that it failed (and still continues to fail) to meet a single one of the four criteria required by the FDA for Fast Track approval. Gardasil is demonstrably neither safer nor more effective than Pap screening combined with the loop electrosurgical excision procedure (LEEP) in preventing cervical cancers, nor can it improve the diagnosis of serious cervical cancer outcomes.

In this regard, Gerhardus and Razum have recently noted that the ‘ … unwarranted confidence in the new [HPV] vaccines led to the impression that there was no need to actually evaluate their effectiveness.’”

I am sure many parents will agree that their words are extremely worrying; however,  what her team uncovered about the safety and efficiency of the HPV vaccines is what I believe parents should be the most concerned about.

They reported:

“Similarly, the notion that HPV vaccines have an impressive safety profile can only be supported by highly flawed design of safety trials and is contrary to accumulating evidence from vaccine safety surveillance databases and case reports which continue to link HPV vaccination to serious adverse outcomes (including death and permanent disabilities). For example, compared to all other vaccines in the U.S. vaccination schedule, Gardasil alone is associated with 61% of all serious adverse reactions (including 63.8% of all deaths and 81.2% cases of permanent disability) in females younger than 30 years of age.

Although a report to a vaccine safety surveillance system does not by itself prove that the vaccine caused an adverse reaction, the unusually high frequency of adverse reactions related to HPV vaccines reported worldwide, as well as their consistent pattern (i.e. nervous system-related disorders rank the highest in frequency), points to a potentially causal relationship. Furthermore, matching the data from vaccine surveillance databases is an increasing number of case reports documenting similar serious adverse reactions associated with HPV vaccine administration, with nervous system and autoimmune disorders being the most frequently reported in the medical literature.” [4]

Dr. Tomljenovic and her team are not alone in their concerns.

Gardasil Reported to Cause Blindness, Autoimmune Disease and Strokes

In 2010, Dr. David Clark, a Functional Neurologist made a short film entitled Gardasil HPV Vaccine Side Effects Story.

During the film, Dr. Clark stated that HPV vaccines can cause blindness, strokes and autoimmune diseases. He went on to explain that although vaccines are designed to stimulate the immune system, in some cases this can cause a catastrophic autoimmune attack on the body, the brain and the nervous system.

He stated that:

“There’s a lot of girls of all ages who are the walking wounded … the walking dead … all from this vaccine.”

Referring to a document written in the Journal of Child Neurology titled A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization Against Human Papilloma Virus,Clark stated that:

“It makes me very, very angry that this is crammed down people’s throats and the public doesn’t think about it.

And I don’t want to see any comments like, ‘Well, this is a rare reaction.’  No, it’s not.  It’s not a rare reaction.  It’s a very common reaction.  There are thousands of women and girls that are suffering. This vaccine has bombarded their immune system and now they have to endure a lifetime of side effects.

See, autoimmune conditions are like a light switch being flipped on.  You can’t just turn them off. That’s why my practice is full of people like this who can’t go anywhere else because no one else knows what to do with them.

So, I guess to get off my soapbox today, if you want to read this study it’s in The Journal of Child Neurology of this year and you can read it for yourself.” [5]

Taking his advice, I decided to read the study.

The study, written by Francis J. DiMario et al., described the case of a 16 year-old girl, who had presented to the emergency room (ER) with visual loss after receiving the Gardasil vaccination.

On examination, the doctors discovered that the previously healthy 16 year-old disclosed a visual acuity of only counting fingers bilaterally and a mild left side weakness which was accompanied by sensory loss at the site of vaccination.

Francis J. DiMario and his team stated:

“Magnetic resonance imaging (MRI) of the brain showed swollen enhancement within the chiasm extending into both retrobulbar optic nerves and a right occipitoparietal lobe mass (later disclosed as tumefactive demyelination) with a large zone of surrounding vasogenic edema.”

In other words, the MRI scan revealed that the patient was suffering from swelling behind both eyes and a mass (tumefactive demyelination) pertaining to the right occipital lobe of the brain.

They concluded:

“It is possible that human papilloma virus was the precipitant for the demyelinating event in the patient presented here. It is tempting to speculate whether there may be a specific immune mechanism initiated with human papilloma virus not yet identified, which resulted in not only acute demyelinating encephalomyelitis but also in an unusual clinical course that resulted in persistent visual loss.” [6]

Whilst their paper did not identify any conclusive evidence that the 16 year-old suffered a visual loss as a direct result of receiving the Gardasil vaccine, their paper is not the only report of visual disturbances being attributed to Gardasil.

The National Vaccine Information Center and sanevax.org have also reported cases of severe visual disturbances after vaccination with Gardasil. [7][8]

More Evidence of Harm

In 2012, the British Medical Journal published a paper by Dr. Deidrie Little titled Premature Ovarian Failure 3 Years After Menarche in a 16 Year-Old Girl Following Human Papillomavirus Vaccination. In her paper, Dr. Little detailed the case of a 16 year-old girl who had suffered a premature menopause after receiving the Gardasil vaccination. Her summary stated:

“Premature ovarian failure in a well adolescent is a rare event. Its occurrence raises important questions about causation, which may signal other systemic concerns. This patient presented with amenorrhoea after identifying a change from her regular cycle to irregular and scant periods following vaccinations against human papillomavirus. She declined the oral contraceptives initially prescribed for amenorrhoea. The diagnostic tasks were to determine the reason for her secondary amenorrhoea and then to investigate for possible causes of the premature ovarian failure identified.

Although the cause is unknown in 90% of cases, the remaining chief identifiable causes of this condition were excluded. Premature ovarian failure was then notified as a possible adverse event following this vaccination. The young woman was counselled regarding preservation of bone density, reproductive implications and relevant follow-up. This event could hold potential implications for population health and prompts further inquiry.” [8]

As the BMJ charges a fee to read their articles, interested readers can find a report about her work and the case on Population Research Institute website. [9]

Conclusion

It is clear from the many reports that I have outlined, that the safety of Gardasil is in question. When you consider that Dr. Tomljenovic, a leading authority on vaccination safety, says that the Gardasil vaccination has failed (and still continues to fail) to meet a single one of the four criteria required by the FDA for Fast Track approval, it is easy to see why.

How many innocent children have to die before governments around the world sit up and take notice?  How many children need to suffer blindness, autoimmune disease, strokes and paralysis as a result of HPV vaccines before our governments say no more?

Read the documents that I have referenced and see for yourself the endless list of serious adverse reactions listed by the National Vaccine Information Center and many others. Ask yourself: is the HPV vaccination and, more importantly, your child’s future health, really worth the risk?

References

  1. http://sanevax.org/
  2. http://fox6now.com/2014/08/07/the-only-thing-different-about-that-day-was-that-shot-did-a-trip-to-the-doctor-kill-a-healthy-12-year-old-girl/
  3. http://thinktwice.com/secret.htm
  4. http://www.infectagentscancer.com/content/8/1/6
  5. http://drclark.typepad.com/dr_david_clark/2010/04/gardasil-hpv-vaccine-side-effects-story.html
  6. http://www.theoneclickgroup.co.uk/documents/vaccines/Visual%20Loss%20Following%20Immunization%20Against%20Human%20Papilloma%20Virus.pdf
  7. http://www.nvic.org/vaccines-and-diseases/HPV/gardasilaug82006.aspx
  8. http://sanevax.org/gardasil-simply-want-healthy-daughter-back/
  9. http://casereports.bmj.com/content/2012/bcr-2012-006879.abstract
  10. http://pop.org/content/teenage-girl-becomes-infertile-after-gardasil-vaccination

Extra research

http://www.thelibertybeacon.com/2014/08/10/gardasil-girls-suffer-from-the-new-autism/

christina_englandChristina was born and educated in London, U.K. In 1978, Christina changed her career path to dedicate her time to caring for the elderly and was awarded the title of Care Giver of the Year for her work with the elderly in 1980. For the last decade, Christina England has been investigating the safety and efficacy of vaccines. Her articles have had over 500,000 hits and she is now known worldwide for her groundbreaking journalism work.

Christina also has created a world first online resource for parents who have lost their children after vaccine injuries … Please visit this site …

Parents & Caregivers Against Medical Injustice

See featured article and more pertinent information here: http://www.missecoglam.com/vaccines/item/7126-website-documents-over-35000-gardasil-horror-stories-how-many-more-will-there-be

 

www.livingwhole.

By:

It’s well-known in this area that I am “in the know” when it comes to parental rights, vaccinations, and how to get your child out of them. People often contact me to figure out what they need to do and where they need to go to pick up one of those cherished exemption forms. Yesterday, I was contacted by a local mother who had attempted to get a religious exemption form in Missouri at their local health department but was told “the state wouldn’t allow them to pass out exemption cards anymore.” 

Right away I smelled a rat. You see, Missouri requires children who attend school to be vaccinated but they also allow both religious and medical exemptions, which requires that a parent go to their local health department to pick up this exemption card to keep on file at their child’s school. I wasn’t aware that Missouri had abolished their religious exemption. If they had, I am sure I would have heard about it on the news. 

So, I stayed up all night stewing over it and set my alarm for 8 a.m. so I could call the “health department in question” and press them on this issue. When the phone rang a pleasant lady answered. I informed her that Missouri law allows one to opt out of vaccinations by filling out a religious exemption card from the health department and I asked if I could pick up a card. She quickly told me that the “state” said they were no longer allowed to pass out religious exemption cards.

After questioning her further she finally suggested I drive a few hours to the health department located in the state capital and maybe they could give me one. Really? There’s new legislation that requires a parent who wants to opt out of vaccinations for religious reasons to drive six or more hours round-trip to get this little card…a little card that the state government’s health website says health departments have on hand?

When I asked her to give me the name and contact information of the person who made this decision she told me to call the health department in Jefferson City (the state capital). I’m guessing she didn’t think I would actually call, but I did. I got on the phone with the Jefferson City Health Department, and ask them what I needed to do to get a religious exemption. They were very nice and respectful of my parental rights and told me I just needed to come in and get an exemption card. Really? That’s it? I said. 

I explained that I was a few hours away and told them what the lady from the local health department had been telling families in the area. I was informed that there was no such requirement that health departments stop passing out religious exemption cards and that I should contact my local health department and tell them to order more. 

I called the local health department back and finally got transferred to someone in charge of their immunization side of things. She gave me the same story, that the state told them they can’t pass out religious exemption cards anymore. And then I informed her that I had contacted the state and this was not the case. I asked her for the person’s contact information who had supposedly told her this and her story changed again. This time, they had run out of religious exemption cards. 

“We’ve had these forms for 20 years. Rarely do people ask for them. We ran out. We are for vaccinations,” she said. 

“That’s great, I replied. I respect your individual beliefs, but some people have religious objections to vaccinations and those people are entitled to their legal exemption, and you are the health department, and you are required to have them on hand.” 

She then informed me that she wasn’t aware of any law that required the health department to provide exemption cards and that if people wanted them they could go to other health departments. “Can’t you just get them in another county, or a drug store, or the library?”

Are you kidding me? You are the local H-E-A-L-T-H Department who serves…the health needs of the locals! No, you cannot get a medical or religious exemption card at the library. I then offered to call the state health department for her and contact members of the local health board and run her thoughts past them.

“I do all the calling about immunizations for this health department,” she said. (Apparently not since she had “forgotten” to order more exemption cards and didn’t have the fake contact information for the imaginary person she supposedly spoke to from the state.) 

By this time she was getting very snarky and defensive. Rightly so. She was just caught in a lie…several actually. I finally got her to “agree” to order more exemption cards to which she replied that they wouldn’t be in for six weeks or so. “You know the state, she said.” In my mind I was thinking, “How ironic that these exemptions will miss getting to the health department before all of the little children have to be vaccinated before attending school.” 

I told her that I was going to call the state and make sure the local health department was rush shipped a batch of religious exemption cards. Then, I told her I would be following up to make sure she received them. And finally, I decided to call the health department board so that they could be apprised that the local health department was misleading individuals into believing their was no vaccine exemption, lying, and not providing the information on vaccination exemptions that the state government assures they will have on hand. 

The Bigger Issue
You would think this event is a rare occurrence, but it’s not. Just last year I ran into the same issue as the mother above when I tried to obtain a medical exemption card from a different health department in a different state. I had to call the state government, the U.S embassy, an immigration doctor, and the CDC before I was told the exemption card I needed was in fact…at the health department…who I had already questioned several times. 

With that being said, individuals and health departments are trying to find (illegal) and strategic ways of infringing upon your vaccination exemptions. Religious exemptions often require that you pick up a card from the health department, but the health departments are telling parents the “state” is not allowing them to pass them out anymore (which is false), and giving people the impression that no religious exemption exists…or telling them they have to drive a few hours to the state capital to get one. They are banking on the fact that you do not have a brain, and that the “hassles” they are imposing will encourage parents to just give up and vaccinate their kids.

What You Should Do
If you are trying to figure out which exemptions your state offers, check out the National Vaccine Information Center’s resource
here. Some schools will accept online copies of these exemptions forms. You can find them here. Some health departments have a downloadable version on their website (though they usually won’t tell you that they do). If your state requires that you pick up a card from your local health department and they make up an excuse for not having them, press them on this issue and hold them accountable. Call the health department at your state capital, notify your legislators, or call your cousin on the local health department board.

To be honest though, a majority of the time questioning what they tell you will do the trick, especially if it is inconsistent with your state’s laws. If you are a fan of parental rights like I am, this issue is too important to ignore.

Hands off my exemption..and hands off yours too! 

 

TLB recommends you visit Living Whole for more great/pertinent articles and information.

See featured article and read comments here: http://www.livingwhole.org/what-to-do-when-youre-told-you-cant-get-a-vaccine-exemption/

gardasil 2Contributed to TLB by: Leslie Carol Botha

Leslie Carol Botha: It is good to see  doctor’s speaking out on this issue.  Cynthia Janak called this years ago when she said “Gardasil girls give the silent faces of Autism a voice.”  Neurological damage is neurological damage – vaccine damage is vaccine damage.

Dr. David Clark, Functional Neurologist, reveals the ugly shocking truth about the Gardasil® HPV Vaccine side effects and how the damage to the nervous system, immune system  and endocrine system of young women is heartbreakingly similar to the MMR vaccine and Autism.

HPV Vaccine Damage Is The New Autism

Dr. ClarkThere are literally thousands of young girls and women in this country right now that have been damaged by the Gardasil vaccine.  You probably haven’t heard of any of these women but I’ve posted on this issue before. The scientific literature is now starting to fill up with case reports and studies and articles that irrefutably show that there is a connection between this vaccine (and it’s an ugly vaccine) and neurological damage.

Now what kind of damage are we talking about?  Well if you simply Google HPV vaccine side effects or vaccine damage, you’re going to find the walking dead.  You’ll see girls that went from smiling and happy one day to being in a wheelchair…from happy to looking like they’ve had a stroke.

It’s like the HPV Vaccine was nuclear bomb that exploded inside their body. 

This vaccine is a really nasty vaccine and the reason HPV vaccine damage is the new autism is because what’s happening to this generation of girls is what happened (and it’s still happening) to a whole generation of children via the MMR vaccine.

SIDE NOTE: mercury is not the only thing that causes autism.  Believe me, I’ve spent 10 years working with these kids and mercury’s not the only factor. Many times it’s the damage from the vaccine, the immunological assault from this vaccine that is catastrophic.

What usually happens to these women and young girls is they now have autoimmune diseases. What that means is that their immune system has been tricked.  It’s been pushed into a state where it’s now attacking their own tissue. These autoimmune conditions won’t necessarily have a name like Multiple Sclerosis or Lupus…but these women and young girls STILL have an autoimmune condition.

What tissues can be attacked and destroyed–causing a tidal wave of problems?  The GI system…the brain…their heart…their muscles.  The immune system can attack anything it wants because remember…

Normally your immune system is kind of naïve when it comes to your own tissue.  It’s never really seen that before and it knows if you will, that it’s not supposed to mobilize and try to kill your own tissues.

With the vaccine damage, especially this vaccine, the immune system gets tricked into thinking that the covering around the nerves in the brain (myelin) needs to be killed.  And so what happens you get a child or young woman who looks like they’re having some sort of acute stroke or maybe even an MS, a Multiple Sclerosis type symptom, and really what they have is they have post vaccine damage.

by Scepcop

Dr. Niall McLaren, an Australian practicing psychiatrist for 22 years, explains what is wrong with the psychiatric profession: That it cannot/will not take criticism, for fear the entire model of biological psychiatry will unravel.

That there is no science to psychiatric diagnoses, no brain based diseases. And that psychiatry only pushes mental disordersas biological disease in order to convince people to take psychiatric drugs, causing a host of dangerous side effects.

For more psychiatrists/psychologists and doctors who have spoken out against the fraud of psychiatry’s biological model of mental disorders (chemical imbalance, etc) click here:http://www.cchrint.org/psychiatric-diso … fic-tests/

Psychiatrists, Physicians & Psychologists That Debunk Psychiatry as a Science, “There are no objective tests in psychiatry-no X-ray, laboratory, or exam finding that says definitively that someone does or does not have a mental disorder.”

— Allen Frances, Former DSM-IV Task Force Chairman “…modern psychiatry has yet to convincingly prove the genetic/biologic cause of any single mental illness…Patients [have] been diagnosed with ‘chemical imbalances’ despite the fact that no test exists to support such a claim, and…there is no real conception of what a correct chemical balance would look like.”

— Dr. David Kaiser, psychiatrist: “There’s no biological imbalance. When people come to me and they say, ‘I have a biochemical imbalance,’ I say, ‘Show me your lab tests.’ There are no lab tests. So what’s the biochemical imbalance?”

— Dr. Ron Leifer, psychiatrist“DSM-IV is the fabrication upon which psychiatry seeks acceptance by medicine in general. Insiders know it is more a political than scientific document… DSM-IV has become a bible and a money making bestseller—its major failings notwithstanding.”

— Loren Mosher, M.D., Clinical Professor of Psychiatry: “All psychiatrists have in common that when they are caught on camera or on microphone, they cower and admit that there are no such things as chemical imbalances/diseases, or examinations or tests for them. What they do in practice, lying in every instance, abrogating [revoking] the informed consent right of every patient and poisoning them in the name of ‘treatment’ is nothing short of criminal.”

— Dr Fred Baughman Jr., Pediatric Neurologist: “Psychiatry makes unproven claims that depression, bipolar illness, anxiety, alcoholism and a host of other disorders are in fact primarily biologic and probably genetic in origin…This kind of faith in science and progress is staggering, not to mention naïve and perhaps delusional.”

— Dr. David Kaiser, psychiatrist : “In short, the whole business of creating psychiatric categories of ‘disease,’ formalizing them with consensus, and subsequently ascribing diagnostic codes to them, which in turn leads to their use for insurance billing, is nothing but an extended racket furnishing psychiatry a pseudo-scientific aura. The perpetrators are, of course, feeding at the public trough.”

— Dr. Thomas Dorman, internist and member of the Royal College of Physicians of the UK: “I believe, until the public and psychiatry itself see that DSM labels are not only useless as medical ‘diagnoses’ but also have the potential to do great harm—particularly when they are used as means to deny individual freedoms, or as weapons by psychiatrists acting as hired guns for the legal system.” — Dr. Sydney Walker III, psychiatrist

“The way things get into the DSM is not based on blood test or brain scan or physical findings. It’s based on descriptions of behavior. And that’s what the whole psychiatry system is.” — Dr. Colin Ross, psychiatrist

“No biochemical, neurological, or genetic markers have been found for Attention Deficit Disorder, Oppositional Defiant Disorder, Depression, Schizophrenia, anxiety, compulsive alcohol and drug abuse, overeating, gambling or any other so-called mental illness, disease, or disorder.” — Bruce Levine, Ph.D., psychologist and author of Commonsense Rebellion

“Unlike medical diagnoses that convey a probable cause, appropriate treatment and likely prognosis, the disorders listed in DSM-IV [and ICD-10] are terms arrived at through peer consensus.” — Tana Dineen Ph.D., Canadian psychologist

Intro to Psychiatry: Industry of Death

“Devotion to the truth is the hallmark of morality; there is no greater, nobler, more heroic form of devotion than the act of a man who assumes the responsibility of thinking.” – Ayn Rand, Atlas Shrugged

 

Read article here: http://www.debunkingskeptics.com/forum/viewtopic.php?t=1497

TLB recommends you read more great/pertinent articles here:  http://www.debunkingskeptics.com/

 



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