FDA chief Califf calls old C-19 Jabs useless to ‘Juice’ boosters

They found the 700 vaccinated patients had increased “myocardial fluorine 18 fluorodeoxyglucose uptake” – a measure of heart inflammation – in scans up to six months after their second mRNA dose compared to 303 unvaccinated, “regardless of sex, age, or type of mRNA vaccine received.” The study also found elevated inflammation in the lymph nodes, liver, and spleen for the vaccinated.A nationwide Austrian study of previously infected individuals, published last month in the peer-reviewed European Journal of Clinical Investigation, found that relative vaccine effectiveness (rVE) for those with four versus three vaccine doses was negative 24% against COVID death, meaning the more-boosted were likelier to die.

While rVE was 17% against infection, the effect “rapidly diminished over time and infection risk with four vaccinations was higher” all the way through June, 7 months after the start of the study period, according to the researchers.

They include Stanford Medical School epidemiologist, meta-research pioneer and lockdown skeptic John Ioannidis, whose early COVID research made him the target of an allegedly retaliatory Stanford investigation.

In March 2020, at the invitation of someone inside the White House, Prof. John Ioannidis organized a group of scientists with diverse views about lockdowns to visit with the US president facing a tremendous choice about extending covid lockdowns.
1/4https://t.co/jBSOYaAKKG

— Jay Bhattacharya (@DrJBhattacharya) June 23, 2023

Califf managed to unite skeptics and boosters of COVID vaccines with his Jan. 2 X thread on the Kaiser Permanente preprint, which has not been peer-reviewed.

It studied how well Pfizer’s updated vaccine that targets now-outdated Omicron variant XBB.1.5 protects against three outcomes in infected people: hospitalization, emergency/urgent care visits, and outpatient visits. Three Pfizer scientists are coauthors.

Researchers compared adults in Kaiser’s Southern California health system who took the new vaccine with those who didn’t, “regardless of prior COVID-19 vaccination or SARS-CoV-2 infection history,” between Oct. 11 and Dec. 10, as well as those who took prior vaccines versus those who were unvaccinated.

The adjusted odds ratio for testing positive for XBB.1.5 vaccine recipients versus everyone else, vaccinated or not, was 0.37-0.42 for the three outcomes, meaning around 60% better protection. The researchers found no “significantly reduced risk” for any outcome for prior-vaccine versus no-vaccine recipients.

Thus, the new vaccines provide “significant additional protection” while previous vaccines offer “little, if any, additional protection […] regardless of the number or type of prior doses received,” they wrote.

Califf’s X thread touting the paper drew a wide range of jeers, especially his claim that it said anyone without updated vaccination “appeared to be unprotected.”

UCSF Medical Center professor Anil Makam called that an “incredibly bad” interpretation.

Califf has gone “full on antivax,” California hospitalist James Lim mused.

This is not true at all.

Previous vaccination with the primary series continues to provide excellent protection against severe disease.

Vaccine effectiveness studies like the one referred to are not able to determine how 1 type of vaccine compares to another and are misleading https://t.co/4yuV8VnrQ6

— Jake Scott, MD (@jakescottMD) January 3, 2024

Former Harvard public health professor Michael Mina, now chief science officer for eMed Digital Healthcare, also called out Califf’s “unprotected” description while dubbing the entire paper “misleading,” in a lengthy X thread.

The idea that the XBB.1.5 formulation is “important” is “total BS and an inappropriate way to read the paper,” Mina said. Because the researchers ran the comparison “a median of 30 days” after receipt of the new vaccine, when immune response is “robust” regardless of formulation, all it shows is “the immune system works!”

The preprint didn’t account for incidental COVID infections in hospitalization or consider whether the updated vaccine “may have just prevented PCR positivity,” Prasad wrote. If its assumption is wrong that “boosted people seek medical care similarly to non boosted people […] it could skew the entire analysis.”

New York Times columnist Zeynep Tufekci, who denied pressuring scientists to walk back their findings on mask effectiveness, dinged Califf’s interpretation without naming him. “People are lying when they claim this paper shows old vaccines aren’t working at all,” Tufekci wrote in an X thread.

“How can the FDA Commissioner misrepresent the science around immunity so badly?” independent Georgia COVID analyst Kelley Krohnert wrote, wondering whether Califf “doesn’t understand [the paper] or if he’s intentionally misrepresenting it.”

She contributed to a Prasad preprint on basic COVID data errors made by the Centers for Disease Control and Prevention.

“The vaccine has benefits in the 60+ and immunocompromised groups” but “much lower” for younger and healthier people, Louisiana nurse practitioner Erin McCabe wrote on X. The CDC and Califf repeatedly omit these nuances, “which is why no one trusts them & thinks they [are] just Pfizer lackeys.”

The vaccine has benefits in the 60+ and immunocompromised groups. The risk for hospitalization & death in younger, healthy people is much lower. Important context the @CDCgov & @DrCaliff_FDA keep leaving out, which is why no one trusts them & thinks they just Pfizer lackeys https://t.co/kG9F7loIHA pic.twitter.com/qHPSJ753hN

— Erin McCabe (@ErinEMcCabe) January 3, 2024

Califf [Pictured below] also claimed just before Christmas, based on a Nature article, that vaccinated children “have a substantially lower rate of Long Covid” than their unvaccinated peers.

The article links to an abstract in the journal Open Forum Infectious Diseases on “post-COVID conditions” in children who were tested for infection weekly for 14 months starting in July 2021. CDC scientists are coauthors of the study, which hasn’t been published in full.

Children were “surveyed via self- or parental report” for six months starting in December 2022, nearly a year and a half after testing started. The two-thirds who were vaccinated – more likely to be white or Asian, previously infected and who reported “excellent/very good” health – were 38-47% less likely to report respiratory PCC and other forms than unvaccinated peers.

“Surely you know this study is observational and full of major confounding,” Krohnert responded to Califf. “And it doesn’t even have the right figures available for people to see” – the tables in the abstract inexplicably refer to PCC in ages 50 and up who took Pfizer’s oral antiviral Paxlovid.

“Kids are not randomly assigned to vaccine, so there is likely residual confounding,” but neither Califf nor Nature appears to have read the tables or they’d realize they “do not match the paper,” Prasad noted. The Paxlovid tables remain on the abstract as of Friday evening, more than a month after it was posted.

The FDA did not respond to Just the News queries to respond to the criticism of Califf’s social media practices and whether he noticed the figures in the long-COVID abstract are wrong.

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(TLB) published this report  with permission of John Solomon at Just the News.  Click Here to read about the staff at Just the News

Header featured image (edited) credit: Cliff/open public card picture

Emphasis added by (TLB)

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