CannaTalk Presents: The Endocannabinoid System (ECS)

Endocannabinoid System (ECS)

By: Chronic Relief

The reasons that cannabis benefits so many different ailments boils down to the fact that a class of chemicals produced in the cannabis plant – known as cannabinoids – mimic chemicals in the human body called endocannabinoids – or the cannabinoids within.

The Endocannabinoid System

These endocannabinoids along with a series of enzymes and receptors throughout the body make up the Endocannabinoid system or the ECS, which serves as a primary biological harm reduction system tasked with bringing the body back into balance or homeostasis whenever it is challenged by stress, infection, injury or lifestyle.

It regulates, modulates or plays role in every major biological function of the human body including but not limited to:

  • pain control

  • mood

  • immune function

  • newborn suckling

  • appetite reward

  • temperature regulation

  • memory

  • inflammation regulation

  • neuroprotection

(Marzo 1998)

The ECS is critical to human survival. At the most basic level it controls how we eat, sleep, relax, forget and protect ourselves.

ECS Stimulation
Graphic by Phytecs

Cannabinoids Boost the Endocannabinoid System

When it is no longer able to regulate itself, cannabinoids and other chemicals from the cannabis plant, when properly used, may help stimulate the ECS in a safe, therapeutic and non-toxic way.

The country’s foremost expert in cannabis science, and my mentor, is neurologist Dr. Ethan Russo. He explains in the document I am providing for you, that the ECS has a network of chemicals that when coupled together result in what is known as an “entourage effect” or a boosting effect that provides an enhancement for the management of pain, inflammation or other problem (Russo 2015).

The same is true for cannabis. The major and minor chemical components of the plant are vastly more therapeutic together than when isolated and together have fewer side-effects (John M. Mcpartland 2001).

It is for this reason that whole-plant cannabis is almost always a more effective medicinal agent than a single isolated product such as CBD-only products or the synthetic THC drug, Marinol® (Russo 2001).

Most pharmaceutical drugs are designed to address a primary problem and bring comfort. Cannabis is much more dynamic, stimulating the ECS to address many problems at once in multiple biological layers, not only bringing comfort but restoration in many cases. And, its safety profile is superior to any modern pharmaceutical medicine – including aspirin. We have more scientific data about cannabis than 95% of all FDA approved drugs (Carter 2014).

It is time that we bring science to the forefront of our cannabis policy and dissolve the cloud of shame, secrecy, and fear around the use of this potentially SAFE and legitimate medicine.

Mary Lynn Mathre with Patient’s Out of Time explains how important the endocannabinoid system is to the body, how it works and how medical marijuana helps our body stay in balance.

For an excellent overview of the Endocannabinoid System, read Ethan Russo’s “Beyond Cannabis: Plants and the Endocannabinoid System“.

For some more detailed information on the ECS read the separate essays of the same title “Introduction to the Endocannabinoid Systemby Dustin Sulak, DO at and then also Dr. Ethan Russo, MD at


Your Guide to Cannabis

Chronic Relief: A Guide to Cannabis for the Terminally and Chronically Ill bridges the gap between the vast amounts of cannabis science and practical application for patients. The book … (TLB: Please click this link & Learn More About the Book)


This article (Endocannabinoid System (ECS)) was originally created and published by Chronic Relief and is republished here under “Fair Use” (see disclaimer below) with attribution to author/website


CannaSense Total Wellness (CTW) can help you/anyone get their medical product legally and become a CannaSense patient or member regardless of what State you may now live in. Go to their website at and sign up today. Tell them we sent you.

Thank you for your support and keep watching and sharing


If you have a story to tell, do a short video recording (computer or smart phone), or write it down and contact us at the CTW email [email protected] for directions on where to upload it to. Your stories can help others so please share …


Please visit us at CannaSense for more information on your health and your rights!



Stay tuned to …


The Liberty Beacon Project is now expanding at a near exponential rate, and for this we are grateful and excited! But we must also be practical. For 7 years we have not asked for any donations, and have built this project with our own funds as we grew. We are now experiencing ever increasing growing pains due to the large number of websites and projects we represent. So we have just installed donation buttons on our websites and ask that you consider this when you visit them. Nothing is too small. We thank you for all your support and your considerations … (TLB)


Comment Policy: As a privately owned web site, we reserve the right to remove comments that contain spam, advertising, vulgarity, threats of violence, racism, or personal/abusive attacks on other users. This also applies to trolling, the use of more than one alias, or just intentional mischief. Enforcement of this policy is at the discretion of this websites administrators. Repeat offenders may be blocked or permanently banned without prior warning.


Disclaimer: TLB websites contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available to our readers under the provisions of “fair use” in an effort to advance a better understanding of political, health, economic and social issues. The material on this site is distributed without profit to those who have expressed a prior interest in receiving it for research and educational purposes. If you wish to use copyrighted material for purposes other than “fair use” you must request permission from the copyright owner.


Disclaimer: The information and opinions shared are for informational purposes only including, but not limited to, text, graphics, images and other material are not intended as medical advice or instruction. Nothing mentioned is intended to be a substitute for professional medical advice, diagnosis or treatment.

Be the first to comment

Leave a Reply

Your email address will not be published.